α-Substituted Chalcones: A Key Review

被引：11

作者：

Al-Rifai, Nafisah M. ^{[1
]}

Mubarak, Mohammad S. ^{[2
]}

机构：

[1] German Jordanian Univ, Sch Med Sci, Pharmaceut & Chem Engn Dept, POB 35247, Amman 111800, Jordan

[2] Univ Jordan, Dept Chem, Amman 11942, Jordan

来源：

CHEMISTRYSELECT | 2021年 / 6卷 / 46期

关键词：

Chalcones; Michael addition; Reactivity tuning; Substituent effects; alpha-Substitution; STEREOSELECTIVE-SYNTHESIS; REGIOSELECTIVE SYNTHESIS; BIOLOGICAL EVALUATION; CARBONYL-COMPOUNDS; VINYL AZIDES; ENANTIOSELECTIVE SYNTHESIS; MULTICOMPONENT REACTION; EFFICIENT SYNTHESIS; MEDIATED SYNTHESIS; ADDITION-REACTION;

D O I：

10.1002/slct.202103325

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chalcones are attractive chemical motifs with various biological activities. Aryl substituted chalcones have been extensively studied and reviewed through the years. However, alpha-substituted chalcones have rarely been investigated. Hence, this review highlights the alpha-substituted chalcones: their synthetic routes, reported biological activities, and transformations to other organic compounds. To the best of our knowledge, this would be the first comprehensive review about alpha-substituted chalcones. alpha-Substitution of chalcones represents a promising approach to tune their reactivity since it has a direct influence on their activity as Michael acceptors. Additionally, alpha-substitution has its effect on the structure and conformation of chalcones. Altering the reactivity of chalcones by alpha-substitution has a great impact on their biological activity.

引用

页码：13224 / 13252

页数：29

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