Interleukin-17 and vascular endothelial growth factor: new biomarkers for the diagnosis of papillary thyroid carcinoma in patients with Hashimoto's thyroiditis

被引：5
作者：
Li, Shuiping [1 ]
Li, Shilin [2 ]
Lin, Min [1 ]
Li, Zuolin [1 ]
He, Jinghua [1 ]
Qiu, Jincheng [1 ]
Zhang, Jiantang [1 ]
机构：
[1] Fujian Med Univ, Dept Ultrasonog, Longyan Affiliated Hosp 1, 105 Jiuyi North Rd, Longyan 364000, Peoples R China
[2] Fujian Med Univ, Dept Ultrasonog, Affiliated Hosp 2, Quanzhou 362000, Peoples R China
来源：
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2022年 / 50卷 / 01期
关键词：
Hashimoto's thyroiditis; papillary thyroid carcinoma; interleukin-17; vascular endothelial growth factor; Hashimoto's thyroiditis with benign nodules; diagnosis biomarker; CANCER; IL-17; CELLS; RISK; COEXISTENT; TH17/TREG; IMBALANCE; DISEASE; IMPACT; VEGF;
D O I：
10.1177/03000605211067121
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Objective The incidences of papillary thyroid carcinoma (PTC) and Hashimoto's thyroiditis (HT) have shown increasing trends. Numerous studies have shown a close relationship between the two diseases, but the exact mechanism linking PTC with HT is still unclear. Interleukin-17 (IL-17) plays an important role in the development of malignant tumors. However, information on the association between IL-17 and thyroid disease is lacking. Methods Tissue samples were collected from patients with thyroid diseases admitted to the thyroid surgery department of our hospital between May 2015 and December 2017. The characteristics of the thyroid were observed by ultrasonography, hematoxylin-eosin staining, enzyme-linked immunosorbent assays, and immunohistochemistry. Results We found that HT with carcinoma (HTC) showed unique characteristics in two-dimensional ultrasound images. Moreover, IL-17 and vascular endothelial growth factor (VEGF) levels showed gradually increasing trends during the process of HT malignant transformation, with a significant positive correlation between the two cytokines. Serum IL-17 and VEGF levels could distinguish between HTC and HT with benign adenoma. Conclusion Our data suggest that serum IL-17 and VEGF levels may represent novel biomarkers for the diagnosis of HT malignant nodules.
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页数：14
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