The Possible Role of Flavonoids in the Prevention of Diabetic Complications

被引：118

作者：

Testa, Roberto ^{[1
]}

Bonfigli, Anna Rita ^{[2
]}

Genovese, Stefano ^{[3
]}

De Nigris, Valeria ^{[4
]}

Ceriello, Antonio ^{[3
,4
,5
]}

机构：

[1] INRCA IRCCS Natl Inst, Expt Models Clin Pathol, I-60127 Ancona, Italy

[2] INRCA IRCCS Natl Inst, Sci Direct, I-60127 Ancona, Italy

[3] IRCCS Multimed, Dept Cardiovasc & Metab Dis, I-20099 Sesto San Giovanni, Italy

[4] IDIBAPS, C Rossello 149-153, Barcelona 08036, Spain

[5] CIBERDEM, Barcelona 08036, Spain

来源：

NUTRIENTS | 2016年 / 8卷 / 05期

关键词：

type 2 diabetes mellitus; diabetic complications; flavonoids; OXIDATIVE STRESS; PERIPHERAL NEUROPATHY; IN-VITRO; ENDOTHELIAL-CELLS; BLOOD-PRESSURE; PLASMA ABNORMALITIES; DIETARY POLYPHENOLS; CITRUS FLAVONOIDS; ALDOSE REDUCTASE; RENAL INJURY;

D O I：

10.3390/nu8050310

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Type 2 diabetes mellitus is a disease that affects many metabolic pathways. It is associated with insulin resistance, impaired insulin signaling, beta-cell dysfunction, abnormal glucose levels, altered lipid metabolism, sub-clinical inflammation and increased oxidative stress. These and other unknown mechanisms lead to micro- and macro-complications, such as neuropathy, retinopathy, nephropathy and cardiovascular disease. Based on several in vitro animal models and some human studies, flavonoids appear to play a role in many of the metabolic processes involved in type 2 diabetes mellitus. In this review, we seek to highlight the most recent papers focusing on the relationship between flavonoids and main diabetic complications.

引用

页数：13