The Possible Role of Flavonoids in the Prevention of Diabetic Complications

被引：123
作者：
Testa, Roberto [1 ]
Bonfigli, Anna Rita [2 ]
Genovese, Stefano [3 ]
De Nigris, Valeria [4 ]
Ceriello, Antonio [3 ,4 ,5 ]
机构：
[1] INRCA IRCCS Natl Inst, Expt Models Clin Pathol, I-60127 Ancona, Italy
[2] INRCA IRCCS Natl Inst, Sci Direct, I-60127 Ancona, Italy
[3] IRCCS Multimed, Dept Cardiovasc & Metab Dis, I-20099 Sesto San Giovanni, Italy
[4] IDIBAPS, C Rossello 149-153, Barcelona 08036, Spain
[5] CIBERDEM, Barcelona 08036, Spain
来源：
NUTRIENTS | 2016年 / 8卷 / 05期
关键词：
type 2 diabetes mellitus; diabetic complications; flavonoids; OXIDATIVE STRESS; PERIPHERAL NEUROPATHY; IN-VITRO; ENDOTHELIAL-CELLS; BLOOD-PRESSURE; PLASMA ABNORMALITIES; DIETARY POLYPHENOLS; CITRUS FLAVONOIDS; ALDOSE REDUCTASE; RENAL INJURY;
D O I：
10.3390/nu8050310
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Type 2 diabetes mellitus is a disease that affects many metabolic pathways. It is associated with insulin resistance, impaired insulin signaling, beta-cell dysfunction, abnormal glucose levels, altered lipid metabolism, sub-clinical inflammation and increased oxidative stress. These and other unknown mechanisms lead to micro- and macro-complications, such as neuropathy, retinopathy, nephropathy and cardiovascular disease. Based on several in vitro animal models and some human studies, flavonoids appear to play a role in many of the metabolic processes involved in type 2 diabetes mellitus. In this review, we seek to highlight the most recent papers focusing on the relationship between flavonoids and main diabetic complications.
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页数：13
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