Converting Poorly Soluble Materials into Stable Aqueous Nanocolloids

被引：81

作者：

Lvov, Yuri M. ^{[1
]}

Pattekari, Pravin ^{[1
]}

Zhang, Xingcai ^{[1
]}

Torchilin, Vladimir ^{[2
,3
]}

机构：

[1] Louisiana Tech Univ, Inst Micromfg, Ruston, LA 71270 USA

[2] Northeastern Univ, Dept Pharmaceut Sci, Boston, MA 02115 USA

[3] Northeastern Univ, Ctr Pharmaceut Biotechnol & Nanomed, Boston, MA 02115 USA

来源：

LANGMUIR | 2011年 / 27卷 / 03期

关键词：

MULTILAYER CAPSULES; SILICA PARTICLES; ENCAPSULATION; RELEASE; MICROCRYSTALS; SONICATION;

D O I：

10.1021/la1041635

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Aqueous nanocolloids of poorly soluble materials were produced via sonicated layer-by-layer (LbL) encapsulation with polycation/polyanion shells. Synergy of simultaneous breaking powder particles with ultrasonication and coating them with polycations allowed for the production of 150-200 nm diameter polyelectrolyte coated nanoparticles with sufficient surface electrical potential for colloidal stability. This technique increases water dispersibility of low soluble materials ranging from anticancer drugs to anticorrosion agents, dyes and inorganic salts.

引用

页码：1212 / 1217

页数：6

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