Value of flow cytometric analysis of peripheral blood samples in children diagnosed with acute lymphoblastic leukemia

被引：5

作者：

Lam, Grace ^{[1
]}

Punnett, Angela ^{[1
]}

Stephens, Derek ^{[2
]}

Sung, Lillian ^{[1
,3
]}

Abdelhaleem, Mohamed ^{[4
]}

Hitzler, Johann ^{[1
,5
]}

机构：

[1] Univ Toronto, Hosp Sick Children, Div Hematol Oncol, Dept Paediat, 55 Univ Ave, Toronto, ON M5G 1X8, Canada

[2] Hosp Sick Children, Clin Res Serv, Toronto, ON, Canada

[3] Hosp Sick Children, Res Inst, Child Hlth Evaluat Sci, Toronto, ON, Canada

[4] Hosp Sick Children, Paediat Lab Med, Toronto, ON, Canada

[5] Hosp Sick Children, Res Inst, Dev & Stem Cell Biol, Toronto, ON, Canada

来源：

PEDIATRIC BLOOD & CANCER | 2018年 / 65卷 / 01期

关键词：

acute lymphoblastic leukemia; diagnosis; flow cytometry; pediatric; peripheral blood;

D O I：

10.1002/pbc.26738

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Diagnostic procedures in children with acute lymphoblastic leukemia (ALL) are typically performed under general anesthesia. Anticipation of the diagnosis based on findings in peripheral blood allows scheduling of the first dose of intrathecal chemotherapy and diagnostic bone marrow (BM) aspirate during a single anesthetic. We retrospectively compared paired results of peripheral blood (PB) flow cytometric analysis and BM evaluation in 383 children with ALL diagnosed consecutively at a single center and found very high concordance of results between both tests. We conclude that PB flow cytometry may help streamline planning of procedure-related anesthetics during diagnosis and early treatment of childhood ALL.

引用

页数：3

共 6 条

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