SNARE-ing the structures of Sec1/Munc18 proteins

被引：26

作者：

Archbold, Julia K. ^{[1
]}

Whitten, Andrew E. ^{[1
]}

Hu, Shu-Hong ^{[1
]}

Collins, Brett M. ^{[2
]}

Martin, Jennifer L. ^{[1
]}

机构：

[1] Univ Queensland, Inst Mol Biosci, Div Chem & Struct Biol, St Lucia, Qld 4072, Australia

[2] Univ Queensland, Inst Mol Biosci, Mol Cell Biol Div, St Lucia, Qld 4072, Australia

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2014年 / 29卷

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

MUNC18-1; DOMAIN; 3A; SYNTAXIN N-PEPTIDE; PLASMA-MEMBRANE; BINDING MODE; COMPLEX; TRAFFICKING; FUSION; SEC1; CONFORMATION; RECRUITMENT;

D O I：

10.1016/j.sbi.2014.09.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Membrane fusion is essential for cellular transport in eukaryotes. Abnormalities contribute to a wide range of diseases including diabetes and neurological disorders. A key regulator of SNARE-mediated membrane fusion is the Sec1/Munc18 (SM) protein family. Universal structural features of SM proteins have been identified that affect the way these interact with their partner Syntaxin SNARE proteins. Whilst the molecular basis for SM-regulated SNARE complex formation has been extensively studied, it remains poorly understood. Recent crystal structures of SM proteins alone or in complex have provided new insight. Here we examine the available structural information on SM proteins for clues to how these enigmatic proteins might regulate SNARE complex assembly and membrane fusion.

引用

页码：44 / 51

页数：8

共 47 条

[1] SNARE zippering requires activation by SNARE-like peptides in Sec1/Munc18 proteins
Yu, Haijia
Shen, Chong
Liu, Yinghui
Menasche, Bridget L.
Ouyang, Yan
Stowell, Michael H. B.
Shen, Jingshi
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (36) : E8421 - E8429
[2] Sec1/Munc18 protein Vps33 binds to SNARE domains and the quaternary SNARE complex
Lobingier, Braden T.
Merz, Alexey J.
MOLECULAR BIOLOGY OF THE CELL, 2012, 23 (23) : 4611 - 4622
[3] The Sec1/Munc18 protein Vps45 holds the Qa-SNARE Tlg2 in an open conformation
Eisemann, Travis J.
Allen, Frederick
Lau, Kelly
Shimamura, Gregory R.
Jeffrey, Philip D.
Hughson, Frederick M.
ELIFE, 2020, 9
[4] Arabidopsis Sec1/Munc18 Protein SEC11 Is a Competitive and Dynamic Modulator of SNARE Binding and SYP121-Dependent Vesicle Traffic
Karnik, Rucha
Grefen, Christopher
Bayne, Robert
Honsbein, Annegret
Koehler, Tim
Kioumourtzoglou, Dimitrios
Williams, Mary
Bryant, Nia J.
Blatt, Michael R.
PLANT CELL, 2013, 25 (04) : 1368 - 1382
[5] Sec1/Munc18 Protein Stabilizes Fusion-Competent Syntaxin for Membrane Fusion in Arabidopsis Cytokinesis
Park, Misoon
Touihri, Sonja
Mueller, Isabel
Mayer, Ulrike
Juergens, Gerd
DEVELOPMENTAL CELL, 2012, 22 (05) : 989 - 1000
[6] The Sec1/Munc18 Protein Groove Plays a Conserved Role in Interaction with Sec9p/SNAP-25
Weber-Boyvat, Marion
Chernov, Konstantin G.
Aro, Nina
Wohlfahrt, Gerd
Olkkonen, Vesa M.
Jantti, Jussi
TRAFFIC, 2016, 17 (02) : 131 - 153
[7] Crystal Structures of the Sec1/Munc18 (SM) Protein Vps33, Alone and Bound to the Homotypic Fusion and Vacuolar Protein Sorting (HOPS) Subunit Vps16
Baker, Richard W.
Jeffrey, Philip D.
Hughson, Frederick M.
PLOS ONE, 2013, 8 (06):
[8] SEC1A is a major Arabidopsis Sec1/Munc18 gene in vesicle trafficking during pollen tube tip growth
Beuder, Steven
Lara-Mondragon, Cecilia
Dorchak, Alexandria
MacAlister, Cora A.
PLANT JOURNAL, 2022, 110 (05) : 1353 - 1369
[9] MEMBRANE FUSION A direct role for the Sec1/Munc18-family protein Vps33 as a template for SNARE assembly
Baker, Richard W.
Jeffrey, Philip D.
Zick, Michael
Phillips, Ben P.
Wickner, William T.
Hughson, Frederick M.
SCIENCE, 2015, 349 (6252) : 1111 - 1114
[10] The Membrane-Associated Sec1/Munc18 KEULE is Required for Phragmoplast Microtubule Reorganization During Cytokinesis in Arabidopsis
Steiner, Alexander
Mueller, Lin
Rybak, Katarzyna
Vodermaier, Vera
Facher, Eva
Thellmann, Martha
Ravikumar, Raksha
Wanner, Gerhard
Hauser, Marie-Theres
Assaad, Farhah F.
MOLECULAR PLANT, 2016, 9 (04) : 528 - 540

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