A Severe Form of Churg-Strauss Syndrome Complicated with Acute Cardiac Failure and Rapidly Progressive Peripheral Neuropathy-A Possible Effect of Intravenous Immunoglobulin Therapy

被引：3

作者：

Kobayashi, Daisuke ^{[1
]}

Wada, Yoko ^{[1
]}

Takata, Takuma ^{[2
]}

Koya, Toshiyuki ^{[3
]}

Murakami, Shuichi ^{[1
]}

Ozawa, Takuya ^{[4
]}

Aizawa, Yoshifusa ^{[4
]}

Kuroda, Takeshi ^{[5
]}

Nakano, Masaaki ^{[6
]}

Narita, Ichiei ^{[1
]}

机构：

[1] Niigata Univ, Grad Sch Med & Dent Sci, Dept Med 2, Div Clin Nephrol & Rheumatol, Niigata 95021, Japan

[2] Nagaoka Cent Gen Hosp, Dept Internal Med, Nagaoka, Niigata, Japan

[3] Niigata Univ, Grad Sch Med & Dent Sci, Dept Med 2, Div Resp Med, Niigata 95021, Japan

[4] Niigata Univ, Grad Sch Med & Dent Sci, Dept Med 1, Div Cardiol, Niigata 95021, Japan

[5] Niigata Univ, Hlth Adm Ctr, Niigata 95021, Japan

[6] Niigata Univ, Fac Med, Sch Hlth Sci, Dept Med Technol, Niigata 95021, Japan

来源：

INTERNAL MEDICINE | 2011年 / 50卷 / 08期

关键词：

Churg-Strauss syndrome (CSS); intravenous administration of a high-dose human immunoglobulin (IVIg); acute cardiac failure; peripheral neuropathy; TERM-FOLLOW-UP; ALLERGIC GRANULOMATOSIS; POLYARTERITIS-NODOSA; MECHANISMS; ANGIITIS;

D O I：

10.2169/internalmedicine.50.4648

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a case of Churg-Strauss syndrome (CSS) complicated by severe cardiac failure and peripheral neuropathy. Two courses of methylprednisolone pulse therapy were unable to control the disease activity. Repeated intravenous administration of high-dose human immunoglobulin (IVIg) was added together with intravenous cyclophosphamide pulse therapy (IVCY), and the patient's cardiac function and neurological symptoms were gradually ameliorated without any adverse event. Although glucocorticoid and cyclophosphamide comprise the standard therapy for patients with CSS, a number of patients with severe complications appear to be resistant to such conventional treatment. IVIg is thought to be an effective therapeutic option for such patients.

引用

页码：925 / 929

页数：5

共 2 条

[1] An aggressive and lethal course of Churg-Strauss syndrome with alveolar hemorrhage, intestinal perforation, cardiac failure and peripheral neuropathy
Ciledag, Aydin
Deniz, Hulya
Eledag, Serpil
Ozkal, Canan
Duzgun, Nursen
Erekul, Selim
Karnak, Demet
RHEUMATOLOGY INTERNATIONAL, 2012, 32 (02) : 451 - 455
[2] Intravenous immunoglobulin for chronic residual peripheral neuropathy in eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome): a multicenter, double-blind trial
Koike, Haruki
Akiyama, Kazuo
Saito, Toyokazu
Sobue, Gen
JOURNAL OF NEUROLOGY, 2015, 262 (03) : 752 - 759

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