Abyssomicin I, a Modified Polycyclic Polyketide from Streptomyces sp. CHI39

被引：41

作者：

Igarashi, Yasuhiro ^{[1
]}

Yu, Linkai ^{[1
]}

Miyanaga, Satoshi ^{[1
]}

Fukuda, Takao ^{[1
]}

Saitoh, Noriko ^{[2
]}

Sakurai, Hiroaki ^{[3
]}

Saiki, Ikuo ^{[3
]}

Alonso-Vega, Pablo ^{[4
]}

Trujillo, Martha E. ^{[4
]}

机构：

[1] Toyama Prefectural Univ, Biotechnol Res Ctr, Toyama 9390398, Japan

[2] Natl Inst Infect Dis, Shinjuku Ku, Tokyo 1628640, Japan

[3] Toyama Univ, Inst Nat Med, Dept Biosci, Toyama 9300194, Japan

[4] Univ Salamanca, Dept Genet & Microbiol, Salamanca 37007, Spain

来源：

JOURNAL OF NATURAL PRODUCTS | 2010年 / 73卷 / 11期

关键词：

MARINE VERRUCOSISPORA STRAIN; GENE-CLUSTER; BIOSYNTHESIS; ACID;

D O I：

10.1021/np100292h

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Abyssomicin I (1), a new modified polycyclic polyketide, was isolated from the culture extract of a soil-derived Streptomyces sp. The structure of 1 was elucidated by interpretation of NMR and other spectroscopic data. The stereochemistry of the new compound was assigned by NOE analysis, chemical derivatization, and application of the modified Mosher method. While 1 was inactive against bacteria and yeasts, the oxidized derivative 7 showed weak activities against Gram-positive bacteria. Compounds 1 and 7 exhibited inhibitory effects on tumor cell invasion with IC50 values of 11 and 0.21 mu M, respectively.

引用

页码：1943 / 1946

页数：4

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