Complete remission of advanced hepatocellular carcinoma by radiofrequency ablation after sorafenib therapy

被引:8
作者
Park, Jung Gil [1 ]
Park, Soo Young [2 ]
Lee, Hye Won [3 ]
机构
[1] CHA Univ, Gumi CHA Med Ctr, Dept Internal Med, Div Gastroenterol & Hepatol, Gumi 730728, South Korea
[2] Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Gastroenterol & Hepatol, Daegu 700721, South Korea
[3] Kyungpook Natl Univ, Sch Med, Dept Pathol, Daegu 700721, South Korea
关键词
Hepatocellular carcinoma; Radiofrequency ablation; Sorafenib; Down-staging; Complete remission; PHASE-II; COMBINATION; TRIAL;
D O I
10.3748/wjg.v21.i8.2568
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Sorafenib, a potent multikinase inhibitor, lead to a significant improvement in progression free survival and overall survival in patients with advanced hepatocellular carcinoma (HCC). Though sorafenib has proven its efficacy in advanced stage HCC, there are limited reports on the role of sorafenib allowing for curative treatment by down-staging. We herein report a case of advanced HCC with vascular invasion, which showed treatment response by sorafenib therapy as to allow for radiofrequency ablation as curative treatment. The patient was followed-up for 6 mo without recurrence with continued sorafenib therapy.
引用
收藏
页码:2568 / 2572
页数:5
相关论文
共 18 条
  • [1] Doxorubicin Plus Sorafenib vs Doxorubicin Alone in Patients With Advanced Hepatocellular Carcinoma A Randomized Trial
    Abou-Alfa, Ghassan K.
    Johnson, Philip
    Knox, Jennifer J.
    Capanu, Marinela
    Davidenko, Irina
    Lacava, Juan
    Leung, Thomas
    Gansukh, Bolorsukh
    Saltz, Leonard B.
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2010, 304 (19): : 2154 - 2160
  • [2] Sustained Remission Over 36 Months of Advanced Hepatocellular Carcinoma After Short-Term Sorafenib Therapy
    Ahn, Sun Young
    Lee, Hyun Seok
    Kweon, Young Oh
    Tak, Won Young
    Park, Soo Young
    [J]. DIGESTIVE DISEASES AND SCIENCES, 2013, 58 (05) : 1428 - 1432
  • [3] Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial
    Cheng, Ann-Lii
    Kang, Yoon-Koo
    Chen, Zhendong
    Tsao, Chao-Jung
    Qin, Shukui
    Kim, Jun Suk
    Luo, Rongcheng
    Feng, Jifeng
    Ye, Shenglong
    Yang, Tsai-Sheng
    Xu, Jianming
    Sun, Yan
    Liang, Houjie
    Liu, Jiwei
    Wang, Jiejun
    Tak, Won Young
    Pan, Hongming
    Burock, Karin
    Zou, Jessie
    Voliotis, Dimitris
    Guan, Zhongzhen
    [J]. LANCET ONCOLOGY, 2009, 10 (01) : 25 - 34
  • [4] Complete Histologic Response Induced by Sorafenib in Advanced Hepatocellular Carcinoma: A Case Report
    Curtit, Elsa
    Thiery-Vuillemin, Antoine
    Nguyen, Thierry
    Heyd, Bruno
    Pivot, Xavier
    Di Martino, Vincent
    Borg, Christophe
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (12) : E330 - E332
  • [5] Selected combination therapy with sorafenib: A review of clinical data and perspectives in advanced solid tumors
    Dal Lago, Lissandra
    D'Hondt, Veronique
    Awada, Ahmad
    [J]. ONCOLOGIST, 2008, 13 (08) : 845 - 858
  • [6] Overview: Where Does Radiation Therapy Fit in the Spectrum of Liver Cancer Local-Regional Therapies?
    Dawson, Laura A.
    [J]. SEMINARS IN RADIATION ONCOLOGY, 2011, 21 (04) : 241 - 246
  • [7] Complete regression induced by sorafenib of locally advanced HCC allowing curative resection
    Irtan, Sabine
    Chopin-Laly, Xavier
    Ronot, Maxime
    Faivre, Sandrine
    Paradis, Valerie
    Belghiti, Jacques
    [J]. LIVER INTERNATIONAL, 2011, 31 (05) : 740 - 743
  • [8] Complete remission of advanced hepatocellular carcinoma by sorafenib: A case report
    Kim, Min Su
    Jin, Young-Joo
    Lee, Jin-Woo
    Lee, Jung-il
    Kim, Young Soo
    Lee, Sun Young
    Chae, Myoung Hun
    [J]. WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2013, 5 (02) : 38 - 42
  • [9] Radiologic complete response with sirolimus and sorafenib in a hepatocellular carcinoma patient who relapsed after orthotopic liver transplantation
    Kim R.
    Aucejo F.
    [J]. Journal of Gastrointestinal Cancer, 2011, 42 (1) : 50 - 53
  • [10] Sorafenib in advanced hepatocellular carcinoma
    Llovet, Josep M.
    Ricci, Sergio
    Mazzaferro, Vincenzo
    Hilgard, Philip
    Gane, Edward
    Blanc, Jean-Frederic
    Cosme de Oliveira, Andre
    Santoro, Armando
    Raoul, Jean-Luc
    Forner, Alejandro
    Schwartz, Myron
    Porta, Camillo
    Zeuzem, Stefan
    Bolondi, Luigi
    Greten, Tim F.
    Galle, Peter R.
    Seitz, Jean-Francois
    Borbath, Ivan
    Haussinger, Dieter
    Giannaris, Tom
    Shan, Minghua
    Moscovici, Marius
    Voliotis, Dimitris
    Bruix, Jordi
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (04) : 378 - 390