Synthesis and antihepatotoxic activity of 2-(substituted-phenyl)-5-(2,3-dihydro-1,4-benzodioxane-2-yl)-1,3,4-oxadiazole derivatives

被引：11

作者：

Ahmed, Bahar ^{[1
]}

Habibullah ^{[1
]}

Khan, Shamshir ^{[1
]}

机构：

[1] Jamia Hamdard, Dept Pharmaceut Chem, Antihepatotox Res Lab, Fac Pharm, New Delhi, India

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2011年 / 26卷 / 02期

关键词：

1; 4-benzodioxane; 3; 4-oxadiazole; antihepatotoxic activity; HERBAL FORMULATION; RATS;

D O I：

10.3109/14756366.2010.489899

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Novel 1,3,4-oxadizole derivatives containing the 1,4-dioxane ring system were synthesised starting from 2,3-dihydro-1,4-benzodioxane-2-carbohydrazide. The synthesised compounds were evaluated for antihepatotoxic activity against CCl(4)-induced hepatotoxicity in rats. Some compounds demonstrated a significant antihepatotoxic activity comparable to the standard drug Silymarin.</.

引用

页码：216 / 221

页数：6

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