Synthesis and antihepatotoxic activity of 2-(substituted-phenyl)-5-(2,3-dihydro-1,4-benzodioxane-2-yl)-1,3,4-oxadiazole derivatives

被引：11
|
作者：
Ahmed, Bahar [1 ]
Habibullah [1 ]
Khan, Shamshir [1 ]
机构：
[1] Jamia Hamdard, Dept Pharmaceut Chem, Antihepatotox Res Lab, Fac Pharm, New Delhi, India
来源：
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2011年 / 26卷 / 02期
关键词：
1; 4-benzodioxane; 3; 4-oxadiazole; antihepatotoxic activity; HERBAL FORMULATION; RATS;
D O I：
10.3109/14756366.2010.489899
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Novel 1,3,4-oxadizole derivatives containing the 1,4-dioxane ring system were synthesised starting from 2,3-dihydro-1,4-benzodioxane-2-carbohydrazide. The synthesised compounds were evaluated for antihepatotoxic activity against CCl(4)-induced hepatotoxicity in rats. Some compounds demonstrated a significant antihepatotoxic activity comparable to the standard drug Silymarin.</.
引用
收藏
页码：216 / 221
页数：6
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