Behcet's (BD) is a systemic inflammatory disease with histological evidence for vasculitis. Leucocyte-leucocyte and leucocyte-endothelial cell interactions are critical in inflammatory reactions that are influenced by the expression, activation and shedding of adhesion molecules. We investigated the expression of some adhesion molecules (E- and L-selectin, VLA-4, ICAM-1, PECAM-1, VCAM-1 and CD18 and CD11c chains of beta-2 integrins) on endothelial and inflammatory cells by immunohistochemistry on cryostat sections of erythema nodosum lesions taken from 15 patients with BD and 12 patients with erythema nodosum of unknown cause. Hematoxylin-eosin stained sections of all specimens were also assessed. The major histopathological findings were perivascular mononuclear cell infiltration and secondary vasculitic changes with no difference between the two groups (P>0.05). However, the frequency of thrombophlebitis was higher in BD (P<0.001). Endothelial and inflammatory cell adhesion molecule expression did not show any significant difference between groups (P>0.05). Although VCAM-1 expression and intensity on endothelial cells of BD patients seemed to be lower, this did not reach statistical significance (P=0.056), We concluded that subcutaneous thrombophlebitis is an important feature of erythema nodosum like lesions in BD, which is almost impossible to understand by physical examination alone. Colchicine, which is known to have some influence on adhesion molecules, might have affected our results, as these showed no significant difference regarding adhesion molecules between the two groups.
机构:
Yonsei Univ, Coll Med, Dept Dermatol, Seoul 120752, South Korea
Yonsei Univ, Coll Med, Cutaneous Biol Res Inst, Seoul 120752, South KoreaYonsei Univ, Coll Med, Dept Dermatol, Seoul 120752, South Korea
Cho, S. B.
Cho, S.
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Yonsei Univ, Coll Med, Dept Dermatol, Seoul 120752, South Korea
Yonsei Univ, Coll Med, Cutaneous Biol Res Inst, Seoul 120752, South KoreaYonsei Univ, Coll Med, Dept Dermatol, Seoul 120752, South Korea
Cho, S.
Lee, J. -H.
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Yonsei Univ, Coll Med, Dept Diagnost Radiol, Div Nucl Med, Seoul 120752, South KoreaYonsei Univ, Coll Med, Dept Dermatol, Seoul 120752, South Korea
Lee, J. -H.
Lee, J. D.
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Yonsei Univ, Coll Med, Dept Diagnost Radiol, Div Nucl Med, Seoul 120752, South KoreaYonsei Univ, Coll Med, Dept Dermatol, Seoul 120752, South Korea
Lee, J. D.
Bang, D.
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Yonsei Univ, Coll Med, Dept Dermatol, Seoul 120752, South Korea
Yonsei Univ, Coll Med, Cutaneous Biol Res Inst, Seoul 120752, South KoreaYonsei Univ, Coll Med, Dept Dermatol, Seoul 120752, South Korea
机构:
Catholic Clin, Dept Dermatohistol, Duisburg, GermanyAlbany Med Coll, Div Dermatopathol, Dept Pathol, Albany, NY 12208 USA
Schaller, Joerg
Carlson, J. Andrew
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Albany Med Coll, Div Dermatopathol, Dept Pathol, Albany, NY 12208 USA
Albany Med Coll, Div Dermatol, Dept Pathol, Albany, NY 12208 USAAlbany Med Coll, Div Dermatopathol, Dept Pathol, Albany, NY 12208 USA
机构:
Univ Ulsan, Dept Dermatol, Asan Med Ctr, Coll Med, Seoul 138736, South KoreaUniv Ulsan, Dept Dermatol, Asan Med Ctr, Coll Med, Seoul 138736, South Korea
Lee, MW
Choi, JH
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Univ Ulsan, Dept Dermatol, Asan Med Ctr, Coll Med, Seoul 138736, South KoreaUniv Ulsan, Dept Dermatol, Asan Med Ctr, Coll Med, Seoul 138736, South Korea
Choi, JH
Sung, KJ
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Univ Ulsan, Dept Dermatol, Asan Med Ctr, Coll Med, Seoul 138736, South KoreaUniv Ulsan, Dept Dermatol, Asan Med Ctr, Coll Med, Seoul 138736, South Korea
Sung, KJ
Moon, KC
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Univ Ulsan, Dept Dermatol, Asan Med Ctr, Coll Med, Seoul 138736, South KoreaUniv Ulsan, Dept Dermatol, Asan Med Ctr, Coll Med, Seoul 138736, South Korea
Moon, KC
Koh, JK
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Univ Ulsan, Dept Dermatol, Asan Med Ctr, Coll Med, Seoul 138736, South KoreaUniv Ulsan, Dept Dermatol, Asan Med Ctr, Coll Med, Seoul 138736, South Korea