Protein-Protein Interactions: Structures and Druggability

被引：10

作者：

Ascher, David B. ^{[1
]}

Jubb, Harry C. ^{[1
]}

Pires, Douglas E. V. ^{[1
]}

Ochi, Takashi ^{[1
]}

Higueruelo, Alicia ^{[1
]}

Blundell, Tom L. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Biochem, Sanger Bldg,Tennis Court Rd, Cambridge CB2 1GA, England

来源：

MULTIFACETED ROLES OF CRYSTALLOGRAPHY IN MODERN DRUG DISCOVERY | 2015年

关键词：

FRAGMENT-BASED DISCOVERY; FREE-ENERGY CALCULATIONS; AMINO-ACID SUBSTITUTION; THERMAL SHIFT ASSAYS; X-RAY-ANALYSIS; DNA-LIGASE IV; HOT-SPOTS; CRYSTAL-STRUCTURE; DRUG DISCOVERY; LEAD DISCOVERY;

D O I：

10.1007/978-94-017-9719-1_12

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

While protein-protein interfaces have promised a range of benefits over conventional sites in drug discovery, they present unique challenges. Here we describe recent developments that facilitate many aspects of the drug discovery process - including characterization and classification of interfaces, identifying druggable sites and strategies for inhibitor development.

引用

页码：141 / 163

页数：23

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