Protein-Protein Interactions: Structures and Druggability

被引：10

作者：

Ascher, David B. ^{[1
]}

Jubb, Harry C. ^{[1
]}

Pires, Douglas E. V. ^{[1
]}

Ochi, Takashi ^{[1
]}

Higueruelo, Alicia ^{[1
]}

Blundell, Tom L. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Biochem, Sanger Bldg,Tennis Court Rd, Cambridge CB2 1GA, England

来源：

MULTIFACETED ROLES OF CRYSTALLOGRAPHY IN MODERN DRUG DISCOVERY | 2015年

关键词：

FRAGMENT-BASED DISCOVERY; FREE-ENERGY CALCULATIONS; AMINO-ACID SUBSTITUTION; THERMAL SHIFT ASSAYS; X-RAY-ANALYSIS; DNA-LIGASE IV; HOT-SPOTS; CRYSTAL-STRUCTURE; DRUG DISCOVERY; LEAD DISCOVERY;

D O I：

10.1007/978-94-017-9719-1_12

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

While protein-protein interfaces have promised a range of benefits over conventional sites in drug discovery, they present unique challenges. Here we describe recent developments that facilitate many aspects of the drug discovery process - including characterization and classification of interfaces, identifying druggable sites and strategies for inhibitor development.

引用

页码：141 / 163

页数：23

共 169 条

[71] Atomic Interactions and Profile of Small Molecules Disrupting Protein-Protein Interfaces: the TIMBAL Database [J].

Higueruelo, Alicia P. ;

Schreyer, Adrian ;

Bickerton, G. Richard J. ;

Pitt, Will R. ;

Groom, Colin R. ;

Blundell, Tom L. .

CHEMICAL BIOLOGY & DRUG DESIGN, 2009, 74 (05) :457-467

[72] Fragment-Based Discovery of the Pyrazol-4-yl Urea (AT9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity [J].

Howard, Steven ;

Berdini, Valerio ;

Boulstridge, John A. ;

Carr, Maria G. ;

Cross, David M. ;

Curry, Jayne ;

Devine, Lindsay A. ;

Early, Theresa R. ;

Fazal, Lynsey ;

Gill, Adrian L. ;

Heathcote, Michelle ;

Maman, Sarita ;

Matthews, Julia E. ;

McMenamin, Rachel L. ;

Navarro, Eva F. ;

O'Brien, Michael A. ;

O'Reilly, Marc ;

Rees, David C. ;

Reule, Matthias ;

Tisi, Dominic ;

Williams, Glyn ;

Vinkovic, Mladen ;

Wyatt, Paul G. .

JOURNAL OF MEDICINAL CHEMISTRY, 2009, 52 (02) :379-388

[73] ASD v2.0: updated content and novel features focusing on allosteric regulation [J].

Huang, Zhimin ;

Mou, Linkai ;

Shen, Qiancheng ;

Lu, Shaoyong ;

Li, Chuangang ;

Liu, Xinyi ;

Wang, Guanqiao ;

Li, Shuai ;

Geng, Lv ;

Liu, Yaqin ;

Wu, Jiawei ;

Chen, Guoqiang ;

Zhang, Jian .

NUCLEIC ACIDS RESEARCH, 2014, 42 (D1) :D510-D516

[74] ASD: a comprehensive database of allosteric proteins and modulators [J].

Huang, Zhimin ;

Zhu, Liang ;

Cao, Yan ;

Wu, Geng ;

Liu, Xinyi ;

Chen, Yingyi ;

Wang, Qi ;

Shi, Ting ;

Zhao, Yaxue ;

Wang, Yuefei ;

Li, Weihua ;

Li, Yixue ;

Chen, Haifeng ;

Chen, Guoqiang ;

Zhang, Jian .

NUCLEIC ACIDS RESEARCH, 2011, 39 :D663-D669

[75] The Ensembl genome database project [J].

Hubbard, T ;

Barker, D ;

Birney, E ;

Cameron, G ;

Chen, Y ;

Clark, L ;

Cox, T ;

Cuff, J ;

Curwen, V ;

Down, T ;

Durbin, R ;

Eyras, E ;

Gilbert, J ;

Hammond, M ;

Huminiecki, L ;

Kasprzyk, A ;

Lehvaslaiho, H ;

Lijnzaad, P ;

Melsopp, C ;

Mongin, E ;

Pettett, R ;

Pocock, M ;

Potter, S ;

Rust, A ;

Schmidt, E ;

Searle, S ;

Slater, G ;

Smith, J ;

Spooner, W ;

Stabenau, A ;

Stalker, J ;

Stupka, E ;

Ureta-Vidal, A ;

Vastrik, I ;

Clamp, M .

NUCLEIC ACIDS RESEARCH, 2002, 30 (01) :38-41

[76] Computational alanine scanning of the 1:1 human growth hormone-receptor complex [J].

Huo, S ;

Massova, I ;

Kollman, PA .

JOURNAL OF COMPUTATIONAL CHEMISTRY, 2002, 23 (01) :15-27

[77] Principles of protein-protein interactions [J].

Jones, S ;

Thornton, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (01) :13-20

[78] Structural biology and drug discovery for protein-protein interactions [J].

Jubb, Harry ;

Higueruelo, Alicia P. ;

Winter, Anja ;

Blundell, Tom L. .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2012, 33 (05) :241-248

[79] PEGylation of interferon α2 improves lymphatic exposure after subcutaneous and intravenous administration and improves antitumour efficacy against lymphatic breast cancer metastases [J].

Kaminskas, Lisa M. ;

Ascher, David B. ;

McLeod, Victoria M. ;

Herold, Marco J. ;

Le, Caroline P. ;

Sloan, Erica K. ;

Porter, Christopher J. H. .

JOURNAL OF CONTROLLED RELEASE, 2013, 168 (02) :200-208

[80] The influence of lead discovery strategies on the properties of drug candidates [J].

Keserue, Gyoergy M. ;

Makara, Gergely M. .

NATURE REVIEWS DRUG DISCOVERY, 2009, 8 (03) :203-212

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