Animal Models of Typical Heterotopic Ossification

被引：55

作者：

Kan, Lixin ^{[1
]}

Kessler, John A. ^{[1
]}

机构：

[1] Northwestern Univ, Feinberg Med Sch, Dept Neurol, Chicago, IL 60611 USA

来源：

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY | 2011年

关键词：

PROGRESSIVE OSSEOUS HETEROPLASIA; BONE MORPHOGENETIC PROTEIN-2; FIBRODYSPLASIA OSSIFICANS; IN-VIVO; MYOSITIS-OSSIFICANS; RABBIT MODEL; CARTILAGE DEVELOPMENT; TRANSGENIC MICE; GROWTH-FACTOR; ECTOPIC BONE;

D O I：

10.1155/2011/309287

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Heterotopic ossification (HO) is the formation of marrow-containing bone outside of the normal skeleton. Acquired HO following traumatic events is a common and costly clinical complication. In contrast, hereditary HO is rarer, progressive, and life-threatening. Substantial effort has been directed towards understanding the mechanisms underlying HO and finding efficient treatments. However, one crucial limiting factor has been the lack of relevant animal models. This article reviews the major currently available animal models, summarizes some of the insights gained from these studies, and discusses the potential future challenges and directions in HO research.

引用

页数：8

共 90 条

[41]

Liu YH, 2000, METH MOL B, V137, P499

[42] PREMATURE SUTURE CLOSURE AND ECTOPIC CRANIAL BONE IN MICE EXPRESSING MSX2 TRANSGENES IN THE DEVELOPING SKULL [J].

LIU, YH ;

KUNDU, R ;

WU, LY ;

LUO, W ;

IGNELZI, MA ;

SNEAD, MI ;

MAXSON, RE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (13) :6137-6141

[43] Identification of Progenitor Cells That Contribute to Heterotopic Skeletogenesis [J].

Lounev, Vitali Y. ;

Ramachandran, Rageshree ;

Wosczyna, Michael N. ;

Yamamoto, Masakazu ;

Maidment, Andrew D. A. ;

Shore, Eileen M. ;

Glaser, David L. ;

Goldhamer, David J. ;

Kaplan, Frederick S. .

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 2009, 91A (03) :652-663

[44] Inhibitory helix-loop-helix transcription factors Id1/Id3 promote bone formation in vivo [J].

Maeda, Y ;

Tsuji, K ;

Nifuji, A ;

Noda, M .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2004, 93 (02) :337-344

[45] Heterotopic ossification: a review [J].

McCarthy, EF ;

Sundaram, M .

SKELETAL RADIOLOGY, 2005, 34 (10) :609-619

[46] THE EFFECT OF DIPHOSPHONATES ON HETEROTOPIC OSSIFICATION IN REGENERATING ACHILLES-TENDON OF THE MOUSE [J].

MCCLURE, J .

JOURNAL OF PATHOLOGY, 1983, 139 (04) :419-430

[47]

MICHELSSON JE, 1994, CLIN ORTHOP RELAT R, P266

[48] MYOSITIS-OSSIFICANS FOLLOWING FORCIBLE MANIPULATION OF THE LEG - A RABBIT MODEL FOR THE STUDY OF HETEROTOPIC BONE-FORMATION [J].

MICHELSSON, JE ;

GRANROTH, G ;

ANDERSSON, LC .

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 1980, 62 (05) :811-815

[49]

Moed B R, 1994, J Arthroplasty, V9, P81, DOI 10.1016/0883-5403(94)90141-4

[50] Overexpression of the Helix-Loop-Helix protein Id2 blocks T cell development at multiple stages [J].

Morrow, MA ;

Mayer, EW ;

Perez, CA ;

Adlam, M ;

Siu, G .

MOLECULAR IMMUNOLOGY, 1999, 36 (08) :491-503

← 1 2 3 4 5 6 7 8 9 →