Animal Models of Typical Heterotopic Ossification

被引：55
作者：
Kan, Lixin [1 ]
Kessler, John A. [1 ]
机构：
[1] Northwestern Univ, Feinberg Med Sch, Dept Neurol, Chicago, IL 60611 USA
来源：
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY | 2011年
关键词：
PROGRESSIVE OSSEOUS HETEROPLASIA; BONE MORPHOGENETIC PROTEIN-2; FIBRODYSPLASIA OSSIFICANS; IN-VIVO; MYOSITIS-OSSIFICANS; RABBIT MODEL; CARTILAGE DEVELOPMENT; TRANSGENIC MICE; GROWTH-FACTOR; ECTOPIC BONE;
D O I：
10.1155/2011/309287
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Heterotopic ossification (HO) is the formation of marrow-containing bone outside of the normal skeleton. Acquired HO following traumatic events is a common and costly clinical complication. In contrast, hereditary HO is rarer, progressive, and life-threatening. Substantial effort has been directed towards understanding the mechanisms underlying HO and finding efficient treatments. However, one crucial limiting factor has been the lack of relevant animal models. This article reviews the major currently available animal models, summarizes some of the insights gained from these studies, and discusses the potential future challenges and directions in HO research.
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页数：8
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