Cross Talk between Wnt/β-Catenin and CIP2A/Plk1 Signaling in Prostate Cancer: Promising Therapeutic Implications

被引：16
作者：
Cristobal, Ion [1 ]
Rojo, Federico [2 ]
Madoz-Gurpide, Juan [2 ]
Garcia-Foncillas, Jesus [1 ]
机构：
[1] UAM, Univ Hosp Fdn Jimenez Diaz, Oncohlth Inst, Translat Oncol Div,IIS Fdn Jimenez Diaz, Madrid, Spain
[2] UAM, IIS Fdn Jimenez Diaz, Dept Pathol, Madrid, Spain
来源：
MOLECULAR AND CELLULAR BIOLOGY | 2016年 / 36卷 / 12期
关键词：
POLO-LIKE-KINASE; SMALL INTERFERING RNA; CELL LUNG-CANCER; BIPOLAR SPINDLE FORMATION; BETA-CATENIN; ANDROGEN RECEPTOR; BREAST-CANCER; PLK1; POLO-LIKE-KINASE-1; PROGNOSTIC-SIGNIFICANCE;
D O I：
10.1128/MCB.00130-16
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Aberrant activation of the Wnt/beta-catenin pathway and polo-like kinase 1 (Plk1) overexpression represent two common events in prostate cancer with relevant functional implications. This minireview analyzes their potential therapeutic significance in prostate cancer based on their role as androgen receptor (AR) signaling regulators and the pivotal role of the tumor suppressor protein phosphatase 2A (PP2A) modulating these pathways.
引用
收藏
页码：1734 / 1739
页数：6
相关论文
共 110 条
[1]   Targeting CDC25C, PLK1 and CHK1 to overcome Docetaxel resistance induced by loss of LZTS1 in prostate cancer [J].
Al Nakouzi, Nader ;
Cotteret, Sophie ;
Commo, Frederic ;
Gaudin, Catherine ;
Rajpar, Shanna ;
Dessen, Philippe ;
Vielh, Philippe ;
Fizazi, Karim ;
Chauchereau, Anne .
ONCOTARGET, 2014, 5 (03) :667-678
[2]   Polo-like kinase 1 (Plk1) inhibits p53 function by physical interaction and phosphorylation [J].
Ando, K ;
Ozaki, T ;
Yamamoto, H ;
Furuya, K ;
Hosoda, M ;
Hayashi, S ;
Fukuzawa, M ;
Nakagawara, A .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (24) :25549-25561
[3]   Silencing of polo-like kinase (Plk) 1 via siRNA causes inhibition of growth and induction of apoptosis in human esophageal cancer cells [J].
Bu, Youquan ;
Yang, Zhengmei ;
Li, Quanhai ;
Song, Fangzhou .
ONCOLOGY, 2008, 74 (3-4) :198-206
[4]  
Chase D, 2000, GENESIS, V26, P26, DOI 10.1002/(SICI)1526-968X(200001)26:1<26::AID-GENE6>3.0.CO
[5]  
2-O
[6]   Up-regulation of Wnt-1 and β-catenin production in patients with advanced metastatic prostate carcinoma -: Potential pathogenetic and prognostic implications [J].
Chen, GP ;
Shukeir, N ;
Potti, A ;
Sircar, K ;
Aprikian, A ;
Goltzman, D ;
Rabbani, SA .
CANCER, 2004, 101 (06) :1345-1356
[7]   Inhibitory effect of Polo-like kinase 1 depletion on mitosis and apoptosis of gastric cancer cells [J].
Chen, Xue-Hua ;
Lan, Bin ;
Qu, Ying ;
Zhang, Xiao-Qing ;
Cai, Qu ;
Liu, Bing-Ya ;
Zhu, Zheng-Gang .
WORLD JOURNAL OF GASTROENTEROLOGY, 2006, 12 (01) :29-35
[8]   Clinicopathological significance of Polo-like kinase 1 (PLK1) expression in human malignant glioma [J].
Cheng, Mao-Wei ;
Wang, Bing-Chan ;
Weng, Zhi-Qiang ;
Zhu, Xiao-Wei .
ACTA HISTOCHEMICA, 2012, 114 (05) :503-509
[9]   Wnt/β-Catenin Signaling and Disease [J].
Clevers, Hans ;
Nusse, Roel .
CELL, 2012, 149 (06) :1192-1205
[10]   Activation of the Tumor Suppressor PP2A Emerges as a Potential Therapeutic Strategy for Treating Prostate Cancer [J].
Cristobal, Ion ;
Gonzalez-Alonso, Paula ;
Daoud, Lina ;
Solano, Esther ;
Torrejon, Blanca ;
Manso, Rebeca ;
Madoz-Gurpide, Juan ;
Rojo, Federico ;
Garcia-Foncillas, Jesus .
MARINE DRUGS, 2015, 13 (06) :3276-3286
12345678910