Effects of ageing on insulin secretion and action

被引：38
|
作者：
Moller, N [1 ]
Gormsen, L
Fuglsang, J
Gjedsted, J
机构：
[1] Aarhus Univ, Inst Expt Res, DK-8000 Aarhus, Denmark
[2] Aarhus Univ, Med Dept Endocrinol & Diabet M, DK-8000 Aarhus, Denmark
来源：
HORMONE RESEARCH | 2003年 / 60卷
关键词：
insulin; insulin resistance; ageing; type 2 diabetes mellitus; insulin secretion;
D O I：
10.1159/000071233
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
One of the many conditions associated with ageing is type 2 diabetes mellitus, the prevalence of which increases from 20-30 years of age onwards. In many cases, type 2 diabetes mellitus is caused by the combination of insulin resistance and poor insulin secretion. Insulin resistance is also a risk factor associated with other disorders, in particular cardiovascular disease. Physiological changes associated with ageing, such as changes in body composition, decreased physical fitness, changes in hormones, and the secondary effects of high levels of free fatty acids and glucose, may also contribute to the impairment of insulin secretion and action. In this review, the effects of ageing on the secretion and action of insulin will be highlighted. Copyright (C) 2003 S. Karger AG, Basel.
引用
收藏
页码：102 / 104
页数：3
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