Lipid Droplet Biogenesis

被引：552
作者：
Walther, Tobias C. [1 ,2 ,3 ,4 ]
Chung, Jeeyun [1 ,2 ]
Farese, Robert V., Jr. [1 ,2 ,3 ]
机构：
[1] Harvard TH Chan Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA
[2] Harvard Med Sch, Dept Cell Biol, Boston, MA 02115 USA
[3] Broad Inst Harvard & MIT, Cambridge, MA 02142 USA
[4] Howard Hughes Med Inst, Boston, MA 02115 USA
来源：
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 33 | 2017年 / 33卷
关键词：
biogenesis; endoplasmic reticulum; lipid droplets; neutral lipids; seipin; sterol esters; triglycerides; triacylglycerol; COA-DIACYLGLYCEROL ACYLTRANSFERASE; ACYL-COA; ENDOPLASMIC-RETICULUM; FAT STORAGE; CHOLESTEROL ACYLTRANSFERASE; TRIACYLGLYCEROL SYNTHESIS; PHOSPHATIDYLCHOLINE SYNTHESIS; CONGENITAL LIPODYSTROPHY; TRANSMEMBRANE PROTEIN-2; PROTEOMIC ANALYSIS;
D O I：
10.1146/annurev-cellbio-100616-060608
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Lipid droplets (LDs) are ubiquitous organelles that store neutral lipids for energy or membrane synthesis and act as hubs for metabolic processes. Cells generate LDs de novo, converting cells to emulsions with LDs constituting the dispersed oil phase in the aqueous cytoplasm. Here we review our current view of LD biogenesis. We present a model of LD formation from the ER in distinct steps and highlight the biology of proteins that govern this biophysical process. Areas of incomplete knowledge are identified, as are connections with physiology and diseases linked to alterations in LD biology.
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收藏
页码：491 / 510
页数：20
相关论文
共 152 条
[11]   Cellular Pathways of Hereditary Spastic Paraplegia [J].
Blackstone, Craig .
ANNUAL REVIEW OF NEUROSCIENCE, VOL 35, 2012, 35 :25-47
[12]   Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes [J].
Brasaemle, DL ;
Dolios, G ;
Shapiro, L ;
Wang, R .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (45) :46835-46842
[13]   Perilipin A increases triacylglycerol storage by decreasing the rate of triacylglycerol hydrolysis [J].
Brasaemle, DL ;
Rubin, B ;
Harten, IA ;
Gruia-Gray, J ;
Kimmel, AR ;
Londos, C .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (49) :38486-38493
[14]   The enzymes of neutral lipid synthesis [J].
Buhman, KK ;
Chen, HC ;
Farese, RV .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (44) :40369-40372
[15]   TIP47 functions in the biogenesis of lipid droplets [J].
Bulankina, Anna V. ;
Deggerich, Anke ;
Wenzel, Dirk ;
Mutenda, Kudzai ;
Wittmann, Julia G. ;
Rudolph, Markus G. ;
Burger, Koert N. J. ;
Hoening, Stefan .
JOURNAL OF CELL BIOLOGY, 2009, 185 (04) :641-655
[16]   Pathophysiology of lipid droplet proteins in liver diseases [J].
Carr, Rotonya M. ;
Ahima, Rexford S. .
EXPERIMENTAL CELL RESEARCH, 2016, 340 (02) :187-192
[17]   Seipin performs dissectible functions in promoting lipid droplet biogenesis and regulating droplet morphology [J].
Cartwright, Bethany R. ;
Binns, Derk D. ;
Hilton, Christopher L. ;
Han, Sungwon ;
Gao, Qiang ;
Goodman, Joel M. .
MOLECULAR BIOLOGY OF THE CELL, 2015, 26 (04) :726-739
[18]   ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase -: Its cloning, expression, and characterization [J].
Cases, S ;
Novak, S ;
Zheng, YW ;
Myers, HM ;
Lear, SR ;
Sande, E ;
Welch', CB ;
Lusis, AJ ;
Spencer, TA ;
Krause, BR ;
Erickson, SK ;
Farese, RV .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (41) :26755-26764
[19]   Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis [J].
Cases, S ;
Smith, SJ ;
Zheng, YW ;
Myers, HM ;
Lear, SR ;
Sande, E ;
Novak, S ;
Collins, C ;
Welch, CB ;
Lusis, AJ ;
Erickson, SK ;
Farese, RV .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (22) :13018-13023
[20]   Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members [J].
Cases, S ;
Stone, SJ ;
Zhou, P ;
Yen, E ;
Tow, B ;
Lardizabal, KD ;
Voelker, T ;
Farese, RV .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (42) :38870-38876
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