Lipid Droplet Biogenesis

被引：552

作者：

Walther, Tobias C. ^{[1
,2
,3
,4
]}

Chung, Jeeyun ^{[1
,2
]}

Farese, Robert V., Jr. ^{[1
,2
,3
]}

机构：

[1] Harvard TH Chan Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA

[2] Harvard Med Sch, Dept Cell Biol, Boston, MA 02115 USA

[3] Broad Inst Harvard & MIT, Cambridge, MA 02142 USA

[4] Howard Hughes Med Inst, Boston, MA 02115 USA

来源：

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 33 | 2017年 / 33卷

关键词：

biogenesis; endoplasmic reticulum; lipid droplets; neutral lipids; seipin; sterol esters; triglycerides; triacylglycerol; COA-DIACYLGLYCEROL ACYLTRANSFERASE; ACYL-COA; ENDOPLASMIC-RETICULUM; FAT STORAGE; CHOLESTEROL ACYLTRANSFERASE; TRIACYLGLYCEROL SYNTHESIS; PHOSPHATIDYLCHOLINE SYNTHESIS; CONGENITAL LIPODYSTROPHY; TRANSMEMBRANE PROTEIN-2; PROTEOMIC ANALYSIS;

D O I：

10.1146/annurev-cellbio-100616-060608

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Lipid droplets (LDs) are ubiquitous organelles that store neutral lipids for energy or membrane synthesis and act as hubs for metabolic processes. Cells generate LDs de novo, converting cells to emulsions with LDs constituting the dispersed oil phase in the aqueous cytoplasm. Here we review our current view of LD biogenesis. We present a model of LD formation from the ER in distinct steps and highlight the biology of proteins that govern this biophysical process. Areas of incomplete knowledge are identified, as are connections with physiology and diseases linked to alterations in LD biology.

引用

页码：491 / 510

页数：20

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