Emerging Roles of Cancer Stem Cells in Bladder Cancer Progression, Tumorigenesis, and Resistance to Chemotherapy: A Potential Therapeutic Target for Bladder Cancer

被引：56

作者：

Abugomaa, Amira ^{[1
,2
]}

Elbadawy, Mohamed ^{[1
,3
]}

Yamawaki, Hideyuki ^{[4
]}

Usui, Tatsuya ^{[1
]}

Sasaki, Kazuaki ^{[1
]}

机构：

[1] Tokyo Univ Agr & Technol, Fac Agr, Dept Vet Med, Lab Vet Pharmacol, 3-5-8 Saiwai Cho, Fuchu, Tokyo 1838509, Japan

[2] Mansoura Univ, Fac Vet Med, Mansoura 35516, Dakahliya, Egypt

[3] Benha Univ, Fac Vet Med, Dept Pharmacol, Toukh 13736, Elqaliobiya, Egypt

[4] Kitasato Univ, Sch Vet Med, Lab Vet Pharmacol, Towada, Aomori 0348628, Japan

来源：

CELLS | 2020年 / 9卷 / 01期

基金：

日本学术振兴会;

关键词：

bladder cancer; cancer stem cells; drug resistance; organoid; molecular targeting therapy; TO-MESENCHYMAL TRANSITION; ALCOHOL-DEHYDROGENASE ISOENZYMES; ANDROGEN DEPRIVATION THERAPY; GROWTH-FACTOR RECEPTOR; URINARY-BLADDER; MOLECULAR CHARACTERIZATION; ALDEHYDE DEHYDROGENASE; SIGNALING PATHWAY; SELF-RENEWAL; EPIGENETIC INACTIVATION;

D O I：

10.3390/cells9010235

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Bladder cancer (BC) is a complex and highly heterogeneous stem cell disease associated with high morbidity and mortality rates if it is not treated properly. Early diagnosis with personalized therapy and regular follow-up are the keys to a successful outcome. Cancer stem cells (CSCs) are the leading power behind tumor growth, with the ability of self-renewal, metastasis, and resistance to conventional chemotherapy. The fast-developing CSC field with robust genome-wide screening methods has found a platform for establishing more reliable therapies to target tumor-initiating cell populations. However, the high heterogeneity of the CSCs in BC disease remains a large issue. Therefore, in the present review, we discuss the various types of bladder CSC heterogeneity, important regulatory pathways, roles in tumor progression and tumorigenesis, and the experimental culture models. Finally, we describe the current stem cell-based therapies for BC disease.

引用

页数：19

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