IGF-I receptor is required for the anabolic actions of parathyroid hormone on bone

被引：107
作者：
Wang, Yongmei
Nishida, Shigeki
Boudignon, Benjamin M.
Burghardt, Andrew
Elalieh, Hashem Z.
Hamilton, Michelle M.
Majumdar, Sharmila
Halloran, Bernard P.
Clernens, Thomas L.
Bikle, Daniel D.
机构：
[1] Vet Affairs Med Ctr, Endocrine Unit, Dept Med, San Francisco, CA 94121 USA
[2] Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA
[3] Univ Alabama Birmingham, Dept Pathol, Div Mol & Cellular Pathol, Birmingham, AL 35294 USA
来源：
JOURNAL OF BONE AND MINERAL RESEARCH | 2007年 / 22卷 / 09期
关键词：
PTH; IGF-I signaling; osteoprogenitor; proliferation; bone formation rate;
D O I：
10.1359/JBMR.070517
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We showed that the IGF-IR-null mutation in mature osteoblasts leads to less bone and decreased periosteal bone formation and impaired the stimulatory effects of PTH on osteoprogenitor cell proliferation and differentiation.
引用
收藏
页码：1329 / 1337
页数：9
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