IGF-I receptor is required for the anabolic actions of parathyroid hormone on bone

被引：106
作者：
Wang, Yongmei
Nishida, Shigeki
Boudignon, Benjamin M.
Burghardt, Andrew
Elalieh, Hashem Z.
Hamilton, Michelle M.
Majumdar, Sharmila
Halloran, Bernard P.
Clernens, Thomas L.
Bikle, Daniel D.
机构：
[1] Vet Affairs Med Ctr, Endocrine Unit, Dept Med, San Francisco, CA 94121 USA
[2] Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA
[3] Univ Alabama Birmingham, Dept Pathol, Div Mol & Cellular Pathol, Birmingham, AL 35294 USA
来源：
JOURNAL OF BONE AND MINERAL RESEARCH | 2007年 / 22卷 / 09期
关键词：
PTH; IGF-I signaling; osteoprogenitor; proliferation; bone formation rate;
D O I：
10.1359/JBMR.070517
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We showed that the IGF-IR-null mutation in mature osteoblasts leads to less bone and decreased periosteal bone formation and impaired the stimulatory effects of PTH on osteoprogenitor cell proliferation and differentiation.
引用
收藏
页码：1329 / 1337
页数：9
相关论文
共 37 条
  • [1] Human parathyroid hormone 1-34 reverses bone loss in ovariectomized mice
    Alexander, JM
    Bab, I
    Fish, S
    Müller, R
    Uchiyama, T
    Gronowicz, G
    Nahounou, M
    Zhao, Q
    White, DW
    Chorev, M
    Gazit, D
    Rosenblatt, M
    [J]. JOURNAL OF BONE AND MINERAL RESEARCH, 2001, 16 (09) : 1665 - 1673
  • [2] Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts - A putative explanation for why intermittent administration is needed for bone anabolism
    Bellido, T
    Ali, AA
    Plotkin, LI
    Fu, Q
    Gubrij, I
    Roberson, PK
    Weinstein, RS
    O'Brien, CA
    Manolagas, SC
    Jilka, RL
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (50) : 50259 - 50272
  • [3] The skeletal structure of insulin-like growth factor I-deficient mice
    Bikle, D
    Majumdar, S
    Laib, A
    Powell-Braxton, L
    Rosen, C
    Beamer, W
    Nauman, E
    Leary, C
    Halloran, B
    [J]. JOURNAL OF BONE AND MINERAL RESEARCH, 2001, 16 (12) : 2320 - 2329
  • [4] Insulin-like growth factor I is required for the anabolic actions of parathyroid hormone on mouse bone
    Bikle, DD
    Sakata, T
    Leary, C
    Elalieh, H
    Ginzinger, D
    Rosen, CJ
    Beamer, W
    Majumdar, S
    Halloran, BP
    [J]. JOURNAL OF BONE AND MINERAL RESEARCH, 2002, 17 (09) : 1570 - 1578
  • [5] Osteoclast differentiation and activation
    Boyle, WJ
    Simonet, WS
    Lacey, DL
    [J]. NATURE, 2003, 423 (6937) : 337 - 342
  • [6] Genetic strategies for elucidating insulin-like growth factor action in bone
    Clemens, TL
    Chernausek, SD
    [J]. GROWTH HORMONE & IGF RESEARCH, 2004, 14 (03) : 195 - 199
  • [7] Effects of daily treatment with parathyroid hormone on bone microarchitecture and turnover in patients with osteoporosis:: A paired biopsy study
    Dempster, DW
    Cosman, F
    Kurland, ES
    Zhou, H
    Nieves, J
    Woelfert, L
    Shane, E
    Plavetic, K
    Müller, R
    Bilezikian, J
    Lindsay, R
    [J]. JOURNAL OF BONE AND MINERAL RESEARCH, 2001, 16 (10) : 1846 - 1853
  • [8] Conditional mutagenesis in mice with heat shock promoter-driven cre transgenes
    Dietrich, P
    Dragatsis, I
    Xuan, SH
    Zeitlin, S
    Efstratiadis, A
    [J]. MAMMALIAN GENOME, 2000, 11 (03) : 196 - 205
  • [9] PTH differentially regulates expression of RANKL and OPG
    Huang, JC
    Sakata, T
    Pfleger, LL
    Bencsik, M
    Halloran, BP
    Bikle, DD
    Nissenson, RA
    [J]. JOURNAL OF BONE AND MINERAL RESEARCH, 2004, 19 (02) : 235 - 244
  • [10] Effects of cyclic vs. daily treatment with human parathyroid hormone (1-34) on murine bone structure and cellular activity
    Iida-Klein, Akiko
    Lu, Shi Shou
    Cosman, Felicia
    Lindsay, Robert
    Dempster, David W.
    [J]. BONE, 2007, 40 (02) : 391 - 398
1234