Endoplasmic reticulum stress response and bile acid signatures associate with multi-strain seroresponsiveness during elderly influenza vaccination

被引：5

作者：

Carre, Christophe ^{[1
]}

Wong, Glenn ^{[2
]}

Narang, Vipin ^{[2
]}

Tan, Crystal ^{[2
]}

Chong, Joni ^{[2
]}

Chin, Hui Xian ^{[2
]}

Xu, Weili ^{[2
]}

Lu, Yanxia ^{[2
]}

Chua, Michelle ^{[2
]}

Poidinger, Michael ^{[2
]}

Tambyah, Paul ^{[3
]}

Nyunt, Ma ^{[3
]}

Ng, Tze Pin ^{[3
]}

Larocque, Daniel ^{[1
]}

Hessler, Catherine ^{[1
]}

Bosco, Nabil ^{[4
]}

Quemeneur, Laurence ^{[1
]}

Larbi, Anis ^{[2
]}

机构：

[1] Sanofi Pasteur, Lyon, France

[2] ASTAR, Immunos, Singapore Immunol Network SIgN, Singapore, Singapore

[3] Natl Univ Singapore Hosp, Div Infect Dis, Singapore, Singapore

[4] Nestle Res, Nestle Inst Hlth Sci, EPFL Innovat Pk, CH-1015 Lausanne, Switzerland

来源：

ISCIENCE | 2021年 / 24卷 / 09期

基金：

英国医学研究理事会;

关键词：

PLASMA-CELL DIFFERENTIATION; SEASONAL INFLUENZA; COGNITIVE IMPAIRMENT; SYSTEMS BIOLOGY; DENDRITIC CELLS; VACCINES; IMMUNITY; ANTIBODY; INHIBITION; PROTECTION;

D O I：

10.1016/j.isci.2021.102970

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The elderly are an important target for influenza vaccination, and the determination of factors that underlie immune responsiveness is clinically valuable. We evaluated the immune and metabolic profiles of 205 elderly Singaporeans administered with Vaxigrip. Despite high seroprotection rates, we observed heterogeneity in the response. We stratified the cohort into complete (CR) or incomplete responders (IR), where IR exhibited signs of accelerated T cell aging. We found a higher upregulation of genes associated with the B-cell endoplasmic-reticulum stress response in CR, where XBP-1 acts as a key upstream regulator. B-cells from IR were incapable of matching the level of XBP-1 upregulation observed in CR after inducing ER stress with tunicamycin in vitro. Metabolic signatures also distinguished CR and IR - as CR presented with a greater diversity of bile acids. Our findings suggest that the ER-stress pathway activation could improve influenza vaccination in the elderly.

引用

页数：25

共 80 条

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