Functional and profiling studies prove that prostate cancer upregulated neuroblastoma thymosin β is the true human homologue of rat thymosin β15

被引：7

作者：

Dhaese, S.

Jonckheere, V.

Goethals, M.

Waltregny, D.

Vandekerckhove, J.

Ampe, C.

Van Troys, M.

机构：

[1] Univ Ghent, Dept Biochem, B-9000 Ghent, Belgium

[2] VIB, VIB Dept Med Protein Res, B-9000 Ghent, Belgium

[3] Univ Liege, Dept Urol, Ctr Expt Can Res, B-4000 Liege, Belgium

来源：

FEBS LETTERS | 2007年 / 581卷 / 25期

关键词：

thymosin; prostate; cancer; actin; cytoskeleton; cell migration;

D O I：

10.1016/j.febslet.2007.09.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A peptide with a sequence identical to rat thymosin beta(Tb)15 was reported to be upregulated in human prostate cancer. However, in this report we provide evidence that TbNB, initially identified in human neuroblastoma, is the only Tb isoform upregulated in human prostate cancer and that the Tb15 sequence is not present herein. In addition, we demonstrate that human TbNB has a higher affinity for actin in comparison to Tb4 and promotes cell migration. In combination, this experimentally validates TbNB as functional homologue of rat Tb15 in the human organism and clarifies the current composition of the human Tb family. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：4809 / 4815

页数：7