Lobectomy vs. sublobectomy for stage I non-small-cell lung cancer: a meta-analysis

被引:6
作者
Lv, Fang [1 ]
Wang, Bing [1 ]
Xue, Qi [1 ]
Gao, Shugeng [1 ]
机构
[1] Chinese Acad Med Sci & Peking Union Med Coll, Dept Thorac Surg, Natl Canc Ctr, Natl Clin Res Ctr Canc,Canc Hosp, Beijing 100021, Peoples R China
关键词
Lobectomy; meta-analysis; non-small-cell lung cancer (NSCLC); sublobectomy; THORACOSCOPIC LOBECTOMY; SUBLOBAR RESECTION; LOCAL RECURRENCE; WEDGE RESECTION; TUMOR SIZE; SEGMENTECTOMY; OUTCOMES; SURVIVAL; CM;
D O I
10.21037/atm-20-460
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Although lobectomy is widely regarded as the treatment of choice for early-stage non-small-cell lung cancer (NSCLC), sublobectomy (segmentectomy and wedge resection) has emerged as an alternative modality over the years. Only a handful of studies has compared the treatment effects of these two surgical interventions. This study aimed to analyze the treatment effects between lobectomy and sublobectomy on the survival outcomes of patients with stage I NSCLC systematically. Methods: PubMed, Embase, and the Cochrane Library were systematically searched from their inception up to February 2019 for studies that compared the survival outcomes of lobectomy and sublobectomy. Studies that reported the diagnosis of stage I NSCLC by imaging or pathophysiology, lobectomy as intervention, sublobectomy as control, and overall survival (OS) and disease-free survival (DFS) as outcomes were included. The mean OS and DFS rates were calculated using the fixed-effects model. Results: A total of 12 studies that included 4,373 patients with stage I NSCLC were included in the meta-analysis. The patients who underwent lobectomy showed a significant improvement in OS than those who underwent sublobectomy (P=0.025). These results differed when stratified by publication year (before 2010 and after 2010), study design (prospective and retrospective), country (Eastern and Western), control (segmentectomy and wedge), and study quality (high and low), but no significant differences were observed in DFS. These results were not altered in the sensitivity and subgroup analyses. Conclusions: Stage I NSCLC patients who undergo sublobectomy display poor OS, whereas the DFS is similar for both methods.
引用
收藏
页数:11
相关论文
共 50 条
  • [21] Comparison of lobectomy and sublobar resection for stage I non-small cell lung cancer: a meta-analysis based on randomized controlled trials
    Lu, Genlin
    Xiang, Zhiyi
    Zhou, Yan
    Dai, Senjie
    Tong, Fei
    Jiang, Renya
    Dai, Min
    Zhang, Qiufeng
    Zhang, Difeng
    FRONTIERS IN ONCOLOGY, 2023, 13
  • [22] Survival Outcomes of Lobectomy Versus Segmentectomy in Clinical Stage I Non-Small Cell Lung Cancer: A Meta-Analysis
    Feng, Jian
    Wang, Li-Feng
    Han, Ting-Yue
    Wang, Yue
    Wu, Xiu-Yu
    Lv, Feng
    Liu, Yang
    Chen, Bing-Hui
    ADVANCES IN THERAPY, 2021, 38 (07) : 4130 - 4137
  • [23] Pulmonary function after segmentectomy versus lobectomy in patients with early-stage non-small-cell lung cancer: a meta-analysis
    Wang, Xinxin
    Guo, Haixie
    Hu, Quanteng
    Ying, Yongquan
    Chen, Baofu
    JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 2021, 49 (09)
  • [24] Sublobar resection versus ablation for stage I non-small-cell lung cancer: a meta-analysis
    Li, Yong
    Yang, Fang
    Huang, Ya-Yong
    Wang, Tao
    JOURNAL OF CARDIOTHORACIC SURGERY, 2022, 17 (01)
  • [25] Survival Following Segmentectomy or Lobectomy in Patients With Stage IB Non-small-cell Lung Cancer
    Hao, Bo
    Zhang, Lin
    Fan, Tao
    Liu, Bohao
    Jiang, Wenyang
    Hu, Hao
    Geng, Qing
    FRONTIERS IN ONCOLOGY, 2020, 10
  • [26] Sublobar resection versus lobectomy for stage IA non-small-cell lung cancer: A systematic review and meta-analysis of randomized controlled trials
    Meldola, Patrick F.
    Toth, Otavio A. S.
    Schnorrenberger, Erick
    Machado, Pablo G.
    Chiarelli, Gabriel F. C.
    Kracik, Jose L. S.
    de Carvalho, Caio C.
    Lobo, Matheus de M.
    Gross, Jefferson L.
    SURGICAL ONCOLOGY-OXFORD, 2023, 51
  • [27] Effectiveness and safety of segmentectomy vs. wedge resection for the treatment of patients with operable non-small cell lung cancer: A meta-analysis and systematic review
    Xiu, Jiawei
    Wang, Shiqi
    Wang, Xilong
    Xu, Wei
    Hu, Yuhang
    Hua, Yujuan
    Xu, Shiguang
    ONCOLOGY LETTERS, 2024, 28 (01)
  • [28] Less is more in solid-dominant lung cancer? Sublobar resection versus lobectomy for solid-dominant stage IA non-small-cell lung cancer: A meta-analysis study
    Guo, Juntang
    Liu, Yang
    Tian, Xiaodong
    Ren, Zhipeng
    Lin, Jixing
    Wang, Bailin
    Liang, Chaoyang
    MOLECULAR AND CLINICAL ONCOLOGY, 2019, 11 (05) : 465 - 473
  • [29] Meta-analysis of intentional sublobar resections versus lobectomy for early stage non-small cell lung cancer
    Cao, Christopher
    Gupta, Sunil
    Chandrakumar, David
    Tian, David H.
    Black, Deborah
    Yan, Tristan D.
    ANNALS OF CARDIOTHORACIC SURGERY, 2014, 3 (02) : 134 - 141
  • [30] Survival Outcomes of Lobectomy Versus Segmentectomy in Clinical Stage I Non-Small Cell Lung Cancer: A Meta-Analysis
    Jian Feng
    Li-Feng Wang
    Ting-Yue Han
    Yue Wang
    Xiu-Yu Wu
    Feng Lv
    Yang Liu
    Bing-Hui Chen
    Advances in Therapy, 2021, 38 : 4130 - 4137