DLC1 and Liver Cancer: The Akt Connection

被引：3
|
作者：
Wuestefeld, Torsten
Zender, Lars [1 ]
机构：
[1] Helmholtz Ctr Infect Res, D-38124 Braunschweig, Germany
来源：
GASTROENTEROLOGY | 2010年 / 139卷 / 04期
关键词：
HUMAN HEPATOCELLULAR-CARCINOMA; GTPASE-ACTIVATING PROTEIN; SUPPRESSOR GENE DLC1; TUMOR-SUPPRESSOR; ABERRANT METHYLATION; PROSTATE-CANCER; CELL; 8P22; EXPRESSION; PROGNOSIS;
D O I：
10.1053/j.gastro.2010.08.016
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
引用
收藏
页码：1093 / 1096
页数：5
相关论文
共 50 条
  • [41] CDK5 is a major regulator of the tumor suppressor DLC1
    Tripathi, Brajendra K.
    Qian, Xiaolan
    Mertins, Philipp
    Wang, Dunrui
    Papageorge, Alex G.
    Carr, Steven A.
    Lowy, Douglas R.
    JOURNAL OF CELL BIOLOGY, 2014, 207 (05): : 627 - 642
  • [42] PKA-induced dimerization of the RhoGAP DLC1 promotes its inhibition of tumorigenesis and metastasis
    Ko, Frankie Chi Fat
    Chan, Lo-Kong
    Sze, Karen Man-Fong
    Yeung, Yin-Shan
    Tse, Edith Yuk-Ting
    Lu, Ping
    Yu, Ming-Hua
    Irene Oi-Lin Ng
    Yam, Judy Wai Ping
    NATURE COMMUNICATIONS, 2013, 4
  • [43] rs621554 single nucleotide polymorphism of DLC1 is associated with breast cancer susceptibility and prognosis
    Ding, Xia
    Gao, Sumei
    Yang, Qifeng
    MOLECULAR MEDICINE REPORTS, 2016, 13 (05) : 4095 - 4100
  • [44] DLC1 deficiency and YAP signaling drive endothelial cell contact inhibition of growth and tumorigenesis
    Ritchey, Lisa
    Ha, Taekyu
    Otsuka, Atsushi
    Kabashima, Kenji
    Wang, Dunrui
    Wang, Yuyi
    Lowy, Douglas R.
    Tosato, Giovanna
    ONCOGENE, 2019, 38 (45) : 7046 - 7059
  • [45] Functional analysis of the Drosophila RhoGAP Cv-c protein and its equivalence to the human DLC3 and DLC1 proteins
    Sotillos, Sol
    Aguilar-Aragon, Mario
    Hombria, James Castelli-Gair
    SCIENTIFIC REPORTS, 2018, 8
  • [46] The tumor suppressor protein DLC1 is regulated by PKD-mediated GAP domain phosphorylation
    Scholz, Rolf-Peter
    Gustafsson, Johan O. R.
    Hoffmann, Peter
    Jaiswal, Mamta
    Ahmadian, Mohammed Reza
    Eisler, Stephan A.
    Erlmann, Patrik
    Schmid, Simone
    Hausser, Angelika
    Olayioye, Monilola A.
    EXPERIMENTAL CELL RESEARCH, 2011, 317 (04) : 496 - 503
  • [47] Full activity of the deleted in liver cancer 1 (DLC1) tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase (FAK)
    Li, Guorong
    Du, Xiaoli
    Vass, William C.
    Papageorge, Alex G.
    Lowy, Douglas R.
    Qian, Xiaolan
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (41) : 17129 - 17134
  • [48] DLC1 SAM domain-binding peptides inhibit cancer cell growth and migration by inactivating RhoA
    Joshi, Rakesh
    Qin, Lyugao
    Cao, Xuan
    Zhong, Shanshan
    Voss, Courtney
    Min, Weiping
    Li, Shawn S. C.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 295 (02) : 645 - 656
  • [49] DLC1 expression is reduced in human cutaneous melanoma and correlates with patient survival
    Sjoestroem, Cecilia
    Khosravi, Shahram
    Cheng, Yabin
    Ardekani, Gholamreza Safaee
    Martinka, Magdalena
    Li, Gang
    MODERN PATHOLOGY, 2014, 27 (09) : 1203 - 1211
  • [50] Identification and characterization of Dlc1 isoforms in the mouse and study of the biological function of a single gene trapped isoform
    Sabbir, Mohammad G.
    Wigle, Nichola
    Loewen, Shauna
    Gu, Yuan
    Buse, Cordula
    Hicks, Geoffrey G.
    Mowat, Michael R. A.
    BMC BIOLOGY, 2010, 8
12345