Pathogenic Role of Epstein-Barr Virus in Lung Cancers

被引：20

作者：

Becnel, David ^{[1
]}

Abdelghani, Ramsy ^{[1
]}

Nanbo, Asuka ^{[2
]}

Avilala, Janardhan ^{[3
,4
]}

Kahn, Jacob ^{[3
,4
]}

Li, Li ^{[5
]}

Lin, Zhen ^{[3
,4
]}

机构：

[1] Tulane Univ, Hlth Sci Ctr, Dept Med, New Orleans, LA 70112 USA

[2] Nagasaki Univ, Natl Res Ctr Control & Prevent Infect Dis, Nagasaki 8528523, Japan

[3] Tulane Univ, Hlth Sci Ctr, Dept Pathol & Lab Med, New Orleans, LA 70112 USA

[4] Tulane Canc Ctr, New Orleans, LA 70112 USA

[5] Ochsner Clin Fdn, Inst Translat Res, New Orleans, LA 70121 USA

来源：

VIRUSES-BASEL | 2021年 / 13卷 / 05期

基金：

美国国家卫生研究院; 日本学术振兴会;

关键词：

non-small cell lung cancer; NSCLC; small cell lung cancer; SCLC; Epstein-Barr virus; EBV; next-generation sequencing; NGS; LYMPHOEPITHELIOMA-LIKE CARCINOMA; GROWTH-FACTOR RECEPTOR; GLOBAL BURDEN; CELL-LINES; RNA; INFECTION; PROTEIN; EXPRESSION; LYMPHOMA; NASOPHARYNGEAL;

D O I：

10.3390/v13050877

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Human oncogenic viruses account for at least 12% of total cancer cases worldwide. Epstein-Barr virus (EBV) is the first identified human oncogenic virus and it alone causes similar to 200,000 cancer cases and similar to 1.8% of total cancer-related death annually. Over the past 40 years, increasing lines of evidence have supported a causal link between EBV infection and a subgroup of lung cancers (LCs). In this article, we review the current understanding of the EBV-LC association and the etiological role of EBV in lung carcinogenesis. We also discuss the clinical impact of the knowledge gained from previous research, challenges, and future directions in this field. Given the high clinical relevance of EBV-LC association, there is an urgent need for further investigation on this topic.

引用

页数：15

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