Inverse association between CSF Aβ 42 levels and years of education in mild form of Alzheimer's disease: The cognitive reserve theory

被引：33

作者：

Dumurgier, Julien ^{[1
]}

Paquet, Claire ^{[1
,2
]}

Benisty, Sarah ^{[1
,3
]}

Kiffel, Claire ^{[1
,3
]}

Lidy, Claude ^{[1
,3
]}

Mouton-Liger, Francois ^{[2
]}

Chabriat, Hugues ^{[4
]}

Laplanche, Jean-Louis ^{[5
]}

Hugon, Jacques ^{[1
,2
]}

机构：

[1] Univ Paris 07, Ctr Memoire Ressources & Rech Paris Nord Ile de F, Fernand Widal Hosp, APHP, Paris, France

[2] Univ Paris 07, Dept Histol & Biol Aging, Fernand Widal Hosp, APHP, Paris, France

[3] Fernand Widal Hosp, Dept Geriatr, Paris, France

[4] Univ Paris 07, Dept Neurol, Fernand Widal Hosp, APHP, Paris, France

[5] Univ Paris 07, Dept Biochem, Fernand Widal Hosp, APHP, Paris, France

来源：

NEUROBIOLOGY OF DISEASE | 2010年 / 40卷 / 02期

关键词：

Alzheimer's disease; CSF; Biomarkers; Cognitive reserve; Amyloid beta peptide; NEOCORTICAL NEUROFIBRILLARY PATHOLOGY; DEMENTIA; BIOMARKERS; HYPOTHESIS; DIAGNOSIS; HUMANS; BRAIN;

D O I：

10.1016/j.nbd.2010.07.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In Alzheimer's disease (AD), the cognitive reserve theory predicts that at any level of assessed clinical severity, the underlying brain pathology is more advanced in patients with more cognitive reserve. Recent evidences suggest that cerebrospinal fluid (CSF) biomarkers may reflect the brain pathology in AD. We investigated the relationship between education level and CSF concentrations of p-amyloid, total tau and phosphorylated tau (ptau-181) in a cohort of 70 subjects newly diagnosed with AD. We report that CSF concentration of beta-amyloid was inversely associated with years of education, after adjustment for age, sex, and severity of the disease. We further demonstrate in stratified analysis that this relation was mainly present in mild form of the disease (CDR1), and was attenuated in more advanced forms of the disease. These results are consistent with the cognitive reserve theory, and suggest that cognitive reserve may be protective against amyloid related cognitive impairment at the onset of the clinical dementia. (c) 2010 Elsevier Inc. All rights reserved.

引用

页码：456 / 459

页数：4

共 25 条

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