Feasibility of mean platelet volume as a biomarker for chronic obstructive pulmonary disease: A systematic review and meta-analysis

被引：4

作者：

Ma, Yiming ^{[1
]}

Zong, Dandan ^{[1
]}

Zhan, Zijie ^{[1
]}

Li, Herui ^{[1
]}

Dai, Zhongshang ^{[1
]}

Cui, Yanan ^{[1
]}

Luo, Lijuan ^{[1
]}

Zeng, Zihang ^{[1
]}

He, Chenjie ^{[1
]}

Chen, Yan ^{[1
]}

机构：

[1] Cent South Univ, Xiangya Hosp 2, Dept Resp & Crit Care Med, Changsha 410011, Hunan, Peoples R China

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2019年 / 47卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Chronic obstructive pulmonary disease; mean platelet volume; biomarker; inflammation; acute exacerbations; meta-analysis; TO-LYMPHOCYTE RATIO; INFLAMMATORY MARKER; ACUTE EXACERBATION; COPD; COMORBIDITY; ACTIVATION; COUNT; MPV;

D O I：

10.1177/0300060519887886

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Objective To evaluate the feasibility of mean platelet volume (MPV) as a biomarker for chronic obstructive pulmonary disease (COPD). Methods A systematic search for studies published up to March 2019 was performed in the PubMed and Web of Science databases. Three independent investigators screened the titles and abstracts of including studies according to eligibility criteria. The Newcastle-Ottawa Scale was used to assess the quality of eligible studies, and statistical analyses were performed using Review Manager version 5.3. Results A total of eight studies with 1230 COPD patients and 443 healthy controls were included in our meta-analysis. No significant differences in MPV level were identified in pairwise comparisons of the acute exacerbations of COPD (AECOPD), stable COPD, and control groups. Furthermore, no significant correlation was observed between MPV level and systemic inflammatory biomarkers. Conclusions MPV does not appear to represent a suitable biomarker of disease phase or inflammatory burden in COPD. However, future large-scale studies should be performed to further investigate the relationship between MPV and COPD.

引用

页码：5937 / 5949

页数：13

共 35 条

[1] The Role of Mean Platelet Volume in Chronic Obstructive Pulmonary Disease Exacerbation [J].