Primary Localized Cutaneous Amyloidosis of Keratinocyte Origin: An Update with Emphasis on Atypical Clinical Variants

被引：20

作者：

Hamie, Lamiaa ^{[1
]}

Haddad, Isabelle ^{[1
]}

Nasser, Nourhane ^{[1
]}

Kurban, Mazen ^{[1
]}

Abbas, Ossama ^{[1
]}

机构：

[1] Amer Univ Beirut, Dept Dermatol, Med Ctr, POB 11-0236, Beirut 11072020, Lebanon

来源：

AMERICAN JOURNAL OF CLINICAL DERMATOLOGY | 2021年 / 22卷 / 05期

关键词：

MACULAR AMYLOIDOSIS; LICHEN AMYLOIDOSIS; CUTIS DYSCHROMICA; POIKILODERMA-LIKE; LASER; MANIFESTATIONS; ASSOCIATION; MANAGEMENT; FEATURES;

D O I：

10.1007/s40257-021-00620-9

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Amyloid is a protein derived from at least 20 different substances. Once misfolded, it results in a group of cutaneous and systemic conditions. Primary localized cutaneous amyloidosis of keratinocyte origin is a very common subtype that can manifest either as lichen or macular amyloidosis, lacking systemic involvement. Lichen amyloidosis often presents as multiple hyperpigmented papules on the lower extremities whereas macular amyloidosis is classically characterized by dark brown rippled macules on the interscapular area. Review of the literature reveals that in addition to the classical presentation of primary localized cutaneous amyloidosis there exists a plethora of various manifestations that can be grouped into either geographic or morphologic categories. This review provides clinicians with the intimate knowledge of these presentations and summarizes the available treatment modalities.

引用

页码：667 / 680

页数：14