Lipid metabolism in cancer: New perspectives and emerging mechanisms

被引:423
作者
Broadfield, Lindsay A. [1 ,2 ,3 ]
Pane, Antonino Alejandro [1 ,2 ,3 ]
Talebi, Ali [4 ]
Swinnen, Johannes, V [4 ]
Fendt, Sarah-Maria [1 ,2 ,3 ]
机构
[1] VIB KU Leuven Ctr Canc Biol, Lab Cellular Metab & Metab Regulat, VIB, Leuven, Belgium
[2] Katholieke Univ Leuven, Dept Oncol, Lab Cellular Metab & Metab Regulat, Leuven, Belgium
[3] Leuven Canc Inst LKI, Leuven, Belgium
[4] Univ Leuven, Leuven Canc Inst LKI, Dept Oncol, KU Leuven,Lab Lipid Metab & Canc, Leuven, Belgium
基金
欧洲研究理事会;
关键词
FATTY-ACID SYNTHASE; COA-DESATURASE; ATP-CITRATE LYASE; METASTASIS-INITIATING CELLS; THERAPEUTIC TARGET; COLORECTAL-CANCER; LUNG-CANCER; TUMOR MICROENVIRONMENT; MEVALONATE PATHWAY; SUPPRESSOR-CELLS;
D O I
10.1016/j.devcel.2021.04.013
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Tumors undergo metabolic transformations to sustain uncontrolled proliferation, avoid cell death, and seed in secondary organs. An increased focus on cancer lipid metabolism has unveiled a number of mechanisms that promote tumor growth and survival, many of which are independent of classical cellular bioenergetics. These mechanisms include modulation of ferroptotic-mediated cell death, support during tumor metastasis, and interactions with the cells of the tumor microenvironment. As such, targeting lipid metabolism for anticancer therapies is attractive, with recent work on small-molecule inhibitors identifying compounds to target lipid metabolism. Here, we discuss these topics and identify open questions.
引用
收藏
页码:1363 / 1393
页数:31
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