Nanomedicine-based strategies to improve treatment of cutaneous leishmaniasis

被引：12

作者：

Goonoo, Nowsheen ^{[1
]}

Huet, Marie Andrea Laetitia ^{[1
]}

Chummun, Itisha ^{[1
]}

Karuri, Nancy ^{[2
]}

Badu, Kingsley ^{[3
]}

Gimie, Fanny ^{[4
]}

Bergrath, Jonas ^{[5
]}

Schulze, Margit ^{[5
]}

Mueller, Mareike ^{[6
,7
]}

Bhaw-Luximon, Archana ^{[1
]}

机构：

[1] Univ Mauritius, Ctr Biomed & Biomat Res, Biomat Drug Delivery & Nanotechnol Unit, Reduit 80837, Mauritius

[2] Dedan Kimathi Univ Technol, Dept Chem Engn, Private Bag 10143 Dedan Kimathi, Nyeri, Kenya

[3] Kwame Nkrumah Univ Sci & Technol, Vector Borne Infect Dis Grp, Theoret & Appl Biol, Kumasi, Ghana

[4] Plateforme Rech CYROI, Animalerie, 2 Rue Maxime Riviere, F-97490 St Clotilde, Ile De La Reuni, France

[5] Univ Appl Sci Bonn Rhein Sieg, Dept Nat Sci, Heisenbergstr 16, D-53359 Rheinbach, Rheinbach, Germany

[6] Univ Siegen, Phys Chem 1, Adolf Reichwein Str 2, D-57076 Siegen, Germany

[7] Univ Siegen, Res Ctr Micro & Nanochem & Bio Technol C, Dept Chem & Biol, Adolf Reichwein Str 2, D-57076 Siegen, Germany

来源：

ROYAL SOCIETY OPEN SCIENCE | 2022年 / 9卷 / 06期

关键词：

leishmaniasis; drug delivery; nanomedicine; scaffolds; tissue engineering; SAND FLY SALIVA; BASIC REPRODUCTION NUMBER; IN-VITRO EVALUATION; ANTILEISHMANIAL ACTIVITY; AMPHOTERICIN-B; NATURAL-PRODUCTS; CHITOSAN NANOPARTICLES; SESQUITERPENE LACTONE; LIGNIN NANOPARTICLES; SILVER NANOPARTICLES;

D O I：

10.1098/rsos.220058

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Nanomedicine strategies were first adapted and successfully translated to clinical application for diseases, such as cancer and diabetes. These strategies would no doubt benefit unmet diseases needs as in the case of leishmaniasis. The latter causes skin sores in the cutaneous form and affects internal organs in the visceral form. Treatment of cutaneous leishmaniasis (CL) aims at accelerating wound healing, reducing scarring and cosmetic morbidity, preventing parasite transmission and relapse. Unfortunately, available treatments show only suboptimal effectiveness and none of them were designed specifically for this disease condition. Tissue regeneration using nano-based devices coupled with drug delivery are currently being used in clinic to address diabetic wounds. Thus, in this review, we analyse the current treatment options and attempt to critically analyse the use of nanomedicine-based strategies to address CL wounds in view of achieving scarless wound healing, targeting secondary bacterial infection and lowering drug toxicity.

引用

页数：28

共 213 条

[81] MATHEMATICAL-MODELING AND THEORY FOR ESTIMATING THE BASIC REPRODUCTION NUMBER OF CANINE LEISHMANIASIS [J].