Generation of broad-spectrum disease resistance by overexpression of an essential regulatory gene in systemic acquired resistance

被引：397
作者：
Cao, H [1 ]
Li, X [1 ]
Dong, XN [1 ]
机构：
[1] Duke Univ, Dept Bot, Dev Cell & Mol Biol Grp, Durham, NC 27708 USA
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1998年 / 95卷 / 11期
关键词：
D O I：
10.1073/pnas.95.11.6531
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The recently cloned NPR1 gene of Arabidopsis thaliana is a key regulator of acquired resistance responses, Upon induction, NPR1 expression is elevated and the NPR1 protein is activated, in turn inducing expression of a battery of downstream pathogenesis-related genes. In this study, we found that NPR1 confers resistance to the pathogens Pseudomonas syringae and Peronospora parasitica in a dosage-dependent fashion. Overexpression of NPR1 leads to enhanced resistance with no obvious detrimental effect on the plants. Thus, for the first time, a single gene is shown to be a workable target for genetic engineering of nonspecific resistance in plants.
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页码：6531 / 6536
页数：6
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