Cerebral Venous Thrombosis after BNT162b2 mRNA SARS-CoV-2 vaccine

被引：71

作者：

Dias, Leonor ^{[1
,2
]}

Soares-Dos-Reis, Ricardo ^{[1
,2
,3
]}

Meira, Joao ^{[4
]}

Ferrao, Diana ^{[5
]}

Soares, Pedro Ribeirinho ^{[5
]}

Pastor, Ana ^{[5
]}

Gama, Guilherme ^{[5
]}

Fonseca, Luisa ^{[5
,6
]}

Fagundes, Vitor ^{[7
]}

Carvalho, Marta ^{[1
,2
]}

机构：

[1] Ctr Hosp Univ Sao Joao, EPE, Dept Neurol, Porto, Portugal

[2] Univ Porto, Fac Med, Clin Neurosci & Mental Hlth Dept, Porto, Portugal

[3] Univ Porto, i3S Inst Res & Innovat Hlth, Porto, Portugal

[4] Ctr Hosp Univ Sao Joao, EPE, Dept Neurossurg, Porto, Portugal

[5] Ctr Hosp Univ Sao Joao, EPE, Dept Internal Med, Stroke Unit, Porto, Portugal

[6] Univ Porto, Fac Med, Med Dept, Porto, Portugal

[7] Ctr Hosp Tamega & Sousa, EPE, Stroke Unit, Porto, Portugal

来源：

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES | 2021年 / 30卷 / 08期

关键词：

Cerebral Venous Thrombosis; COVID-19; SARS-CoV-2; Thromboembolism;

D O I：

10.1016/j.jstrokecerebrovasdis.2021.105906

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The development of SARS-CoV-2 vaccines has raised several concerns regarding venous thromboembolism, namely cerebral venous thrombosis. Although cerebral venous thrombosis has been reported after administration of a viral vector vaccine, due to a possible auto-immune mechanism inducing thrombocytopenia, the same has not happened in mRNA vaccines. We report two cases of cerebral venous thrombosis, shortly after administration of mRNA vaccine. In both patients, there was no evidence of thrombocytopenia or anti platelet antibodies, and alternative causes for cerebral venous thrombosis were found. As such, despite the temporal relation of both cases to vaccine administration, these types of cerebral venous thrombosis do not seem to be pathophysiological different from cerebral venous thrombosis not associated to SARS-CoV-2 vaccination. Continuous pharmacovigilance is necessary to monitor possible new events and clarify this association.

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