CBS reductions with a fluorous prolinol immobilized in a hydrofluoroether solvent

被引：35

作者：

Chu, Qianli ^{[1
,2
]}

Yu, Marvin S. ^{[1
]}

Curran, Dennis P. ^{[2
]}

机构：

[1] Fluorous Technol Inc, UPARC, Pittsburgh, PA 15238 USA

[2] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 05期

关键词：

D O I：

10.1021/ol702778v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A fluorous prolinol precatalyst bearing only 34 fluorine atoms has been immobilized in the hydrofluoroether solvent HFE-7500. The,CBS reduction of acetophenone proceeded rapidly, in high yield and in high ee in the absence of any organic solvent. The organic product was stripped from the HFE-7500 phase with a polar solvent, and the HFE-7500 phase was reused "as is" with satisfactory results through eight runs. This process is an attractive prototype for the large-scale use, recovery, and reuse of fluorous organocatalysts.

引用

页码：749 / 752

页数：4

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