Oxidative and malondialdehyde modification of low-density lipoprotein: a comparative study of binding and degradation by macrophages and endothelial cells

被引：0

作者：

Zhou, M ^{[1
]}

Chen, Y

Liu, SX

Ding, ZH

Pang, ZJ

Wan, J

机构：

[1] First Mil Med Univ, Res Lab Free Radical Med, Guangzhou 510515, Peoples R China

[2] Univ Hong Kong, Dept Zool, Hong Kong, Peoples R China

来源：

BRITISH JOURNAL OF BIOMEDICAL SCIENCE | 1998年 / 55卷 / 03期

关键词：

binding; competitive; lipoproteins; LDL; macrophages; malondialdelhyde modification; oxidative modification; receptors;

D O I：

暂无

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Comparative study of oxidatively modified low-density lipoprotein (Ox-LDL) and malondialdehyde-modified low-density lipoprotein (MDA-LDL) is important for further understanding the biological properties of Ox-LDL, such as its toxic effects, immunogenicity and multiplicity of scavenger receptor binding. In this study, the characteristics of Ox-LDL and MDA-LDL binding and degradation were compared. The results show that when their degree of modification (as determined by relative electrophoretic mobility) was similar, the binding and degradation of Ox-LDL by the macrophage cell line P388D1 were greater than those of MDA-LDL. The binding and degradation of Ox-LDL by macrophages and human umbilical vein endothelial cells increased with the degree of modification. In addition, Ox-LDL or MDA-LDL could competitively inhibit binding of labelled Ox-LDL or labelled MDA-LDL to their respective macrophage receptors, and could partially inhibit each other.

引用

页码：192 / 198

页数：7

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