NO points to epigenetics in vascular development

被引：10

作者：

Illi, Barbara ^{[2
]}

Colussi, Claudia ^{[3
]}

Rosati, Jessica ^{[1
]}

Spallotta, Francesco ^{[3
]}

Nanni, Simona ^{[4
]}

Farsetti, Antonella ^{[5
]}

Capogrossi, Maurizio C. ^{[1
]}

Gaetano, Carlo ^{[1
]}

机构：

[1] Ist Dermopat Immacolata, Lab Patol Vasc, I-00167 Rome, Italy

[2] IRCCS Casa Sollievo Sofferenza, Mendel Lab, San Giovanni Rotondo, Italy

[3] IRCCS, Ctr Cardiol Monzino, Milan, Italy

[4] Univ Cattolica Sacro Cuore, Ist Patol Med, Rome, Italy

[5] Ist Neurobiol & Med Mol, Consiglio Nazl Ric CNR, Rome, Italy

来源：

CARDIOVASCULAR RESEARCH | 2011年 / 90卷 / 03期

关键词：

Epigenetics; Vascular development; Nitric oxide; EMBRYONIC STEM-CELLS; NITRIC-OXIDE SYNTHASE; HISTONE DEACETYLASE ACTIVITY; IN-VITRO MODEL; FACTOR-KAPPA-B; GENE-EXPRESSION; PROGENITOR CELLS; TRANSCRIPTIONAL REPRESSION; ENDOTHELIAL-CELLS; BINDING PROTEIN;

D O I：

10.1093/cvr/cvr056

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Our understanding of epigenetic mechanisms important for embryonic vascular development and cardiovascular differentiation is still in its infancy. Although molecular analyses, including massive genome sequencing and/or in vitro/in vivo targeting of specific gene sets, has led to the identification of multiple factors involved in stemness maintenance or in the early processes of embryonic layers specification, very little is known about the epigenetic commitment to cardiovascular lineages. The object of this review will be to outline the state of the art in this field and trace the perspective therapeutic consequences of studies aimed at elucidating fundamental epigenetic networks. Special attention will be paid to the emerging role of nitric oxide in this field.

引用

页码：447 / 456

页数：10

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