Langerhans cells in innate defense against pathogens

被引：39
作者：
de Jong, Marein A. W. P. [1 ,2 ,3 ]
Geijtenbeek, Teunis B. H. [1 ,2 ]
机构：
[1] Univ Amsterdam, Acad Med Ctr, Ctr Infect & Immun Amsterdam, NL-1105 AZ Amsterdam, Netherlands
[2] Univ Amsterdam, Acad Med Ctr, Ctr Expt & Mol Med, NL-1105 AZ Amsterdam, Netherlands
[3] Univ Amsterdam, Acad Med Ctr, Dept Cell Biol & Histol, NL-1105 AZ Amsterdam, Netherlands
来源：
TRENDS IN IMMUNOLOGY | 2010年 / 31卷 / 12期
关键词：
C-TYPE LECTIN; HUMAN-IMMUNODEFICIENCY-VIRUS; TUMOR-NECROSIS-FACTOR; SEXUALLY-TRANSMITTED-DISEASES; GRAM-POSITIVE BACTERIA; TARGETS DC-SIGN; DENDRITIC CELLS; HIV-1; TRANSMISSION; BIRBECK GRANULES; CUTTING EDGE;
D O I：
10.1016/j.it.2010.08.002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Langerhans cells (LCs) are at the frontline in defense against mucosal infections because they line the mucosal tissues and are ideally situated to intercept pathogens. Recent data suggest that LCs have an innate anti-HIV-1 function. LCs express the LC-specific C-type lectin Langerin that efficiently captures HIV-1, which prevents HIV-1 transmission. However, immune activation of LCs changes these protective cells into HIV-1-transmitting cells, which indicates that the antiviral function of LCs depends on several factors including co-infections. In this review, we discuss the dual role of LCs in innate defense against pathogens, with a focus on HIV-1 dissemination.
引用
收藏
页码：452 / 459
页数：8
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