ALDH1: A potential therapeutic target for cancer stem cells in solid tumors

被引:47
作者
Wei, Yaolu [1 ]
Li, Yan [1 ]
Chen, Yenan [2 ]
Liu, Pei [2 ]
Huang, Sheng [2 ]
Zhang, Yuping [1 ]
Sun, Yanling [1 ]
Wu, Zhe [1 ]
Hu, Meichun [1 ]
Wu, Qian [1 ]
Wu, Hongnian [1 ]
Liu, Fuxing [1 ]
She, Tonghui [1 ]
Ning, Zhifeng [1 ]
机构
[1] Hubei Univ Sci & Technol, Xianning Med Coll, Sch Basic Med Sci, Xianning, Peoples R China
[2] Hubei Univ Sci & Technol, Xianning Med Coll, Xianning, Peoples R China
来源
FRONTIERS IN ONCOLOGY | 2022年 / 12卷
基金
中国国家自然科学基金;
关键词
ALDH1; stem cell markers; solid tumors; targeted therapy; cancer resistance; DEHYDROGENASE; 1A1; ALDH1A1; ALDEHYDE DEHYDROGENASE; POOR-PROGNOSIS; ESOPHAGEAL CANCER; OVARIAN-CANCER; MARKERS ALDH1; DNA-DAMAGE; EXPRESSION; CARCINOMA; METASTASIS;
D O I
10.3389/fonc.2022.1026278
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Solid tumors can be divided into benign solid tumors and solid malignant tumors in the academic community, among which malignant solid tumors are called cancers. Cancer is the second leading cause of death in the world, and the global incidence of cancer is increasing yearly New cancer patients in China are always the first. After the concept of stem cells was introduced in the tumor community, the CSC markers represented by ALDH1 have been widely studied due to their strong CSC cell characteristics and potential to be the driving force of tumor metastasis. In the research results in the past five years, it has been found that ALDH1 is highly expressed in various solid cancers such as breast cancer, lung cancer, colorectal cancer, liver cancer, gastric cancer, cervical cancer, esophageal cancer, ovarian cancer, head,and neck cancer. ALDH1 can activate and transform various pathways (such as the USP28/MYC signaling pathway, ALDH1A1/HIF-1 alpha/VEGF axis, wnt/beta-catenin signaling pathway), as well as change the intracellular pH value to promote formation and maintenance, resulting in drug resistance in tumors. By targeting and inhibiting ALDH1 in tumor stem cells, it can enhance the sensitivity of drugs and inhibit the proliferation, differentiation, and metastasis of solid tumor stem cells to some extent. This review discusses the relationship and pathway of ALDH1 with various solid tumors. It proposes that ALDH1 may serve as a diagnosis and therapeutic target for CSC, providing new insights and new strategies for reliable tumor treatment.
引用
收藏
页数:14
相关论文
共 50 条
  • [21] Glyoxalase 1 as a Therapeutic Target in Cancer and Cancer Stem Cells
    Kim, Ji-Young
    Jung, Ji-Hye
    Lee, Seung-Joon
    Han, Seon-Sook
    Hong, Seok-Ho
    MOLECULES AND CELLS, 2022, 45 (12) : 869 - 876
  • [22] Cancer stem cells and their potential implications for the treatment of solid tumors
    Grotenhuis, B. A.
    Wijnhoven, B. P. L.
    Van Lanschot, J. J. B.
    JOURNAL OF SURGICAL ONCOLOGY, 2012, 106 (02) : 209 - 215
  • [23] Evaluation of ALDH1 expression in ipsilateral breast cancer recurrence
    Shien, Tadahiko
    Tanaka, Takehiro
    Tanabe, Masahiko
    Okumura, Yasuhiro
    Masuda, Norikazu
    Yoshida, Atsushi
    Arima, Nobuyuki
    Komoike, Yoshifumi
    Tanaka, Satoru
    Iwase, Takuji
    Taguchi, Tetsuya
    Nakatsukasa, Katsuhiko
    Inaji, Hideo
    Ishitobi, Makoto
    ONCOLOGY LETTERS, 2017, 13 (03) : 1071 - 1077
  • [24] The prognostic impact of cancer stem-like cell biomarker aldehyde dehydrogenase-1 (ALDH1) in ovarian cancer: A meta-analysis
    Ruscito, Ilary
    Darb-Esfahani, Silvia
    Kulbe, Hagen
    Bellati, Filippo
    Zizzari, Ilaria Grazia
    Koshkaki, Hassan Rahimi
    Napoletano, Chiara
    Caserta, Donatella
    Rughetti, Aurelia
    Kessler, Mirjana
    Sehouli, Jalid
    Nuti, Marianna
    Braicu, Elena Ioana
    GYNECOLOGIC ONCOLOGY, 2018, 150 (01) : 151 - 157
  • [25] ALDH1-High Ovarian Cancer Stem-Like Cells Can Be Isolated from Serous and Clear Cell Adenocarcinoma Cells, and ALDH1 High Expression Is Associated with Poor Prognosis
    Kuroda, Takafumi
    Hirohashi, Yoshihiko
    Torigoe, Toshihiko
    Yasuda, Kazuyo
    Takahashi, Akari
    Asanuma, Hiroko
    Morita, Rena
    Mariya, Tasuku
    Asano, Takuya
    Mizuuchi, Masahito
    Saito, Tsuyoshi
    Sato, Noriyuki
    PLOS ONE, 2013, 8 (06):
  • [26] Mining distinct aldehyde dehydrogenase 1 (ALDH1) isoenzymes in gastric cancer
    Shen, Jia-Xin
    Liu, Jing
    Li, Guan-Wu
    Huang, Yi-Teng
    Wu, Hua-Tao
    ONCOTARGET, 2016, 7 (18) : 25340 - 25349
  • [27] In Situ Identification of Putative Cancer Stem Cells by Multiplexing ALDH1, CD44, and Cytokeratin Identifies Breast Cancer Patients with Poor Prognosis
    Neumeister, Veronique
    Agarwal, Seema
    Bordeaux, Jennifer
    Camp, Robert L.
    Rimm, David L.
    AMERICAN JOURNAL OF PATHOLOGY, 2010, 176 (05) : 2131 - 2138
  • [28] Ovarian cancer stem cell: A potential therapeutic target for overcoming multidrug resistance
    Mihanfar, Aynaz
    Attari, Javad Aghazadeh
    Mohebbi, Iraj
    Majidinia, Maryam
    Kaviani, Mojtaba
    Yousefi, Mehdi
    Yousefi, Bahman
    JOURNAL OF CELLULAR PHYSIOLOGY, 2019, 234 (04) : 3238 - 3253
  • [29] Cancer stem cells in solid tumors
    Hermann, Patrick C.
    Bhaskar, Sonu
    Cioffi, Michele
    Heeschen, Christopher
    SEMINARS IN CANCER BIOLOGY, 2010, 20 (02) : 77 - 84
  • [30] Potential role of cancer stem cells as biomarkers and therapeutic targets in cervical cancer
    Sudhalkar, Niyati
    Rathod, Nidul P.
    Mathews, Ashwathi
    Chopra, Supriya
    Sriram, Harshini
    Shrivastava, Shyam K.
    Goda, Jayant S.
    CANCER REPORTS, 2019, 2 (02)