Insight Into the Roles of Non-coding RNA in Bronchopulmonary Dysplasia

被引：7
作者：
Xi, Yufeng [1 ]
Wang, Yujia [1 ,2 ]
机构：
[1] Univ Elect Sci & Technol China, Sch Med, Chengdu Womens & Childrens Cent Hosp, Dept Neonatol, Chengdu, Sichuan, Peoples R China
[2] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Dept Dermatol, Chengdu, Sichuan, Peoples R China
来源：
FRONTIERS IN MEDICINE | 2021年 / 8卷
关键词：
bronchopulmonary dysplasia; premature infants; noncoding RNA; microRNA; long non-coding RNA; CHRONIC LUNG-DISEASE; PRETERM INFANTS; UNIQUE FEATURES; UP-REGULATION; LNCRNA H19; INFLAMMATION; EXPRESSION; CELLS; MICRORNAS; CLUSTER;
D O I：
10.3389/fmed.2021.761724
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Bronchopulmonary dysplasia (BPD) is a chronic lung disease most commonly occurring in premature infants, and its pathological manifestations are alveolar hypoplasia and dysregulation of pulmonary vasculature development. The effective treatment for BPD has not yet been established. Non-coding RNAs, including microRNAs and long non-coding RNAs do not encode proteins, but can perform its biological functions at the RNA level. Non-coding RNAs play an important role in the incidence and development of BPD by regulating the expression of genes related to proliferation, apoptosis, angiogenesis, inflammation and other cell activities of alveolar epithelial cells and vascular endothelial cells. Here we summarize the role of non-coding RNAs in BPD, which provides possible molecular marker and therapeutic target for the diagnosis and treatment of BPD.
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页数：8
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