Multicomponent Assembly of Trisubstituted Imidazoles and Their Photochemical Cyclization into Fused Polyheterocyclic Scaffolds

被引：10

作者：

Gapanenok, Diana ^{[1
]}

Makhmet, Azat ^{[1
,2
,3
]}

Peshkov, Anatoly A. ^{[1
]}

Smirnova, Darya ^{[1
]}

Amire, Niyaz ^{[3
]}

Peshkov, Vsevolod A. ^{[3
]}

Spiridonova, Darya ^{[1
]}

Dar'in, Dmitry ^{[1
]}

Balalaie, Saeed ^{[4
]}

Krasavin, Mikhail ^{[1
,5
]}

机构：

[1] St Petersburg State Univ, Inst Chem, St Petersburg 199034, Russia

[2] LN Gumilyov Eurasian Natl Univ, Dept Chem, Nur Sultan 010000, Kazakhstan

[3] Nazarbayev Univ, Sch Sci & Humanities, Dept Chem, Nur Sultan 010000, Kazakhstan

[4] KN Toosi Univ Technol, Peptide Chem Res Ctr, Tehran 19697, Iran

[5] Immanuel Kant Baltic Fed Univ, Kaliningrad 236016, Russia

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 87卷 / 12期

基金：

美国国家科学基金会;

关键词：

BIGINELLI REACTION; 3-COMPONENT REACTION; DERIVATIVES; HETEROCYCLES; ALKALOIDS; EFFICIENT; CATALYST; DIHYDROPYRIMIDINONES; INDOLES; FACILE;

D O I：

10.1021/acs.joc.2c00475

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A straightforward route to a large and diverse library of trisubstituted imidazoles was established via a three component reaction of 2-oxoaldehydes, 1,3-dicarbonyl compounds, and acyclic nitrogen bis-nucleophiles. The obtained products were subsequently explored in a photochemical cyclization yielding a variety of imidazole-fused polycyclic compounds.

引用

页码：7838 / 7851

页数：14

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