p53, ROS and senescence in the control of aging

被引：185
|
作者：
Vigneron, Arnaud [1 ]
Vousden, Karen H. [1 ]
机构：
[1] Beatson Inst Canc Res, Glasgow G61 1BD, Lanark, Scotland
来源：
AGING-US | 2010年 / 2卷 / 08期
关键词：
CELLULAR SENESCENCE; TUMOR SUPPRESSION; ACETYLATION; PATHWAY; STRESS; CELLS; CYCLE;
D O I：
10.18632/aging.100189
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In addition to its function as a tumour suppressor, p53 is also involved in an increasing number of pathology associated with aging. Several activities of p53 appear contribute to its role in aging; one function that might be particularly relevant in this context is the regulation of senescence. The control of ROS and senescence by p53 may help to explain how p53 can function to both restrain and promote aging.
引用
收藏
页码：471 / 474
页数：4
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