Platelet-derived growth factor, transforming growth factor-β, and connective tissue growth factor in a porcine bronchial model of obliterative bronchiolitis

被引：13
作者：
Alho, Hanni S.
Maasilta, Paula K.
Vainikka, Tiina
Salminen, Ulla-Stina
机构：
[1] Helsinki Univ Hosp, Dept Surg, FIN-00029 Helsinki, Finland
[2] Paijat Hame Cent Hosp, Dept Surg, Lahti, Finland
来源：
EXPERIMENTAL LUNG RESEARCH | 2007年 / 33卷 / 06期
关键词：
CTGF; experimental lung transplantation; imatinib; obliterative bronchiolitis; PDGF; TGF-beta;
D O I：
10.1080/01902140701539745
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
The expression of platelet-derived growth factor (PDGF), transforming growth factor (TGF)-beta, and connective tissue growth factor (CTGF) and the effect of imatinib, an agent inhibiting PDGF receptors, were assessed in a porcine bronchial transplantation model of obliterative bronchiolitis (OB). Up-regulation of PDGF-A, PDGF receptors alpha and beta, and TCF-beta expression occurred in allografts, whereas PDGF-B and CTGF expression was similar in allo- and autografts. Imatinib modified the inflammatory responses and expression patterns of PDGF-A and PDGF receptors. This study, further confirms PDCF and TGF-beta as mediators of OB and supports the concept of the importance of the pathways signaled through PDGF receptors in post-transplant OB.
引用
收藏
页码：303 / 320
页数：18
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