Histone Deacetylase Inhibitor for NUT Midline Carcinoma

被引：61

作者：

Maher, Ossama M. ^{[1
,5
]}

Christensen, Anthony M. ^{[2
]}

Yedururi, Sireesha ^{[3
]}

Bell, Diana ^{[4
]}

Tarek, Nidale ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Pediat, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Pharm Clin Programs, Houston, TX 77030 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Radiol, Houston, TX 77030 USA

[4] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA

[5] Cairo Univ, Natl Canc Inst, Dept Pediat, Cairo, Egypt

来源：

PEDIATRIC BLOOD & CANCER | 2015年 / 62卷 / 04期

关键词：

histone deacetylase inhibitor; NUT midline carcinoma; VORINOSTAT; CONSORTIUM; TRIAL;

D O I：

10.1002/pbc.25350

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

NUT Midline carcinoma (NMC) is a rare and invariably fatal poorly differentiated carcinoma characterized by chromosomal rearrangement involving the nuclear protein of the testis (NUT) gene. Current approaches do not provide durable response. We report a case of widely metastatic NMC in a 17-year-old female who, following an initial response to combination chemotherapy developed rapid disease progression. Treatment with vorinostat, a histone deacetylase inhibitor (HDACi) resulted in an objective response, yet she died in less than one year from initial diagnosis. This report shows a potentially promising activity of HDACi in the treatment of NMC that needs further exploration. Pediatr Blood Cancer 2015;62:715-717. (c) 2015 Wiley Periodicals, Inc.

引用

页码：715 / 717

页数：3

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