Iridoid glycosides and lignans from the fruits of Gardenia jasminoides Eills

被引：19

作者：

Cao, Yan-Gang ^{[1
,2
]}

Ren, Ying-Jie ^{[1
,2
]}

Liu, Yan-Ling ^{[1
,2
]}

Wang, Meng-Na ^{[1
,2
]}

He, Chen ^{[1
,2
]}

Chen, Xu ^{[1
,2
]}

Fan, Xi-Ling ^{[1
,2
]}

Zhang, Yan-Li ^{[1
,2
]}

Hao, Zhi-You ^{[1
,2
]}

Li, Hong-Wei ^{[1
,2
]}

Zheng, Xiao-Ke ^{[1
,2
,3
,4
]}

Feng, Wei-Sheng ^{[1
,2
,3
,4
]}

机构：

[1] Henan Univ Chinese Med, Sch Pharm, Zhengzhou 450046, Peoples R China

[2] Engn & Technol Ctr Chinese Med Dev Henan Prov, Zhengzhou 450046, Peoples R China

[3] Coconstruct Collaborat Innovat Ctr Chinese Med &, Zhengzhou 450046, Peoples R China

[4] Educ Minist PR China, Zhengzhou 450046, Peoples R China

来源：

PHYTOCHEMISTRY | 2021年 / 190卷

基金：

中国国家自然科学基金;

关键词：

Gardenia jasminoides Eills; Rubiaceae; Iridoid glycosides; Lignans; alpha-glucosidase inhibitory activity; AERIAL PARTS; GLUCOSIDES; CONSTITUENTS; BARK; SPECTROSCOPY; C-13;

D O I：

10.1016/j.phytochem.2021.112893

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four previously undescribed iridoid glycosides, including two bis-iridoid glycosides, and three undescribed lignans, together with 16 known analogues, were isolated from the fruits of Gardenia jasminoides Eills. Their structures were elucidated on basis of spectroscopic methods, and the absolute configurations of three of the unknown compounds were determined by interpretation of their electronic circular dichroic (ECD) and [alpha](20)(D) data. The alpha-glucosidase inhibitory effects of the isolated compounds were evaluated and all the compounds exhibited slightly inhibitory activity with the values of IC50 greater than 50 mu M.

引用

页数：8

共 35 条

[1] C-13 NMR SPECTRAL INVESTIGATIONS .9. C-13 NMR-SPECTROSCOPY OF LIGNAN AND NEOLIGNAN DERIVATIVES [J].