Nitric Oxide Photoreleasers with Fluorescent Reporting

被引：24

作者：

Fraix, Aurore ^{[1
]}

Parisi, Cristina ^{[1
]}

Seggio, Mimimorena ^{[1
]}

Sortino, Salvatore ^{[1
]}

机构：

[1] Univ Catania, Dept Drug & Hlth Sci, PhotoChemLab, I-95125 Catania, Italy

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2021年 / 27卷 / 50期

关键词：

nitric oxide; light; fluorescence imaging; therapy; PHOTOREMOVABLE PROTECTING GROUPS; REACTION-MECHANISMS; CARBON DOTS; RELEASE; NO; MICROSCOPY; BIOLOGY; CHEMISTRY; DELIVERY; DONORS;

D O I：

10.1002/chem.202101662

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nitric oxide (NO) plays a multifaceted role in human physiology and pathophysiology, and its controlled delivery has great prospects in therapeutic applications. The light-activated uncaging of NO from NO caging compounds allows this free radical to be released with accurate control of site and dosage, which strictly determine its biological effects. Molecular constructs able to activate fluorescence concomitantly to NO release offer the important advantage of easy and real-time tracking of the amount of NO uncaged in a non-invasive fashion even in the cell environment. This contribution provides an overview of the advances in photoactivatable NO releasers bearing fluorescent reporting functionalities achieved in our and other laboratories, highlighting the rationale design and their potential therapeutic applications.

引用

页码：12714 / 12725

页数：12

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