Effects of pinostrobin on estrogen metabolism and estrogen receptor transactivation

被引：52

作者：

Le Bail, JC ^{[1
]}

Aubourg, L ^{[1
]}

Habrioux, G ^{[1
]}

机构：

[1] Fac Pharm, Biochim Lab, UPRES EA 1085, F-87025 Limoges, France

来源：

CANCER LETTERS | 2000年 / 156卷 / 01期

关键词：

aromatase; estrogen receptor; pinostrobin; phytoestrogens; MCF-7;

D O I：

10.1016/S0304-3835(00)00435-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The interaction between the estrogen receptor and 5-hydroxy-7-methoxyflavanone (pinostrobin) was studied in the presence or absence of estradiol or dehydroepiandrosterone sulfate (DHEAS), respectively, using a stably transfected human breast cancer cell line (MVLN). We also evaluated its action on the proliferation in estrogen-dependent (MCF-7) human breast cancer cells in the same conditions than the estrogen receptor assay. On the other hand pinostrobin was evaluated for their effects on the human placental aromatase, 3 beta -hydroxysteroid dehydrogenase Delta (4)/Delta (5) isomerase and 17 beta -hydroxysteroid dehydrogenase activities. Pinostrobin did not possess antiestrogenic activity but presented anti-aromatase activity and decreased the growth of MCF-7 cells induced by DHEAS and E-2. This study provides particularly evidence of the potential biological interest of pinostrobin among the flavonoids. (C) 2000 Elsevier Science Ireland Ltd. Ail rights reserved.

引用

页码：37 / 44

页数：8

共 32 条

[1] INHIBITION OF HUMAN AROMATASE BY MAMMALIAN LIGNANS AND ISOFLAVONOID PHYTOESTROGENS [J].

ADLERCREUTZ, H ;

BANNWART, C ;

WAHALA, K ;

MAKELA, T ;

BRUNOW, G ;

HASE, T ;

AROSEMENA, PJ ;

KELLIS, JT ;

VICKERY, LE .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1993, 44 (02) :147-153

[2] 2,6-bis((3,4-dihydroxyphenyl)-methylene)cyclohexanone (BDHPC)-induced apoptosis and p53-independent growth inhibition: Synergism with genistein [J].

Attalla, H ;

Makela, TP ;

Wahala, K ;

Rasku, S ;

Andersson, LC ;

Adlercreutz, H .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 239 (02) :467-472

[3] A novel activity for a group of sesquiterpene lactones: Inhibition of aromatase [J].

Blanco, JG ;

Gil, RR ;

Alvarez, CI ;

Patrito, LC ;

GentiRaimondi, S ;

Flury, A .

FEBS LETTERS, 1997, 409 (03) :396-400

[4]

CASSADY JM, 1988, CANCER RES, V48, P6257

[5]

Clark JW, 1996, INT J CANCER, V65, P186

[6] The estrogenic and antiestrogenic activities of phytochemicals with human estrogen receptor expressed in yeast [J].

Collins, BM ;

McLachlan, JA ;

Arnold, SF .

STEROIDS, 1997, 62 (04) :365-372

[7]

Dickancaite E, 1998, BIOCHEM MOL BIOL INT, V45, P923

[8] CONTROL OF AROMATASE IN BREAST-CANCER CELLS AND ITS IMPORTANCE FOR TUMOR-GROWTH [J].

DOWSETT, M ;

MACAULAY, V ;

GLEDHILL, J ;

RYDE, C ;

NICHOLLS, J ;

ASHWORTH, A ;

MCKINNA, JA ;

SMITH, IE .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1993, 44 (4-6) :605-609

[9] ANTIESTROGENS, DIFFERENT SITES OF ACTION THAN THE ESTROGEN-RECEPTOR [J].

FAYE, JC ;

FARGIN, A ;

VALETTE, A ;

BAYARD, F .

HORMONE RESEARCH, 1987, 28 (2-4) :202-211

[10] AROMATASE INHIBITION BY FLAVONOIDS [J].

IBRAHIM, AR ;

ABULHAJJ, YJ .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1990, 37 (02) :257-260

← 1 2 3 4 →