Tryptophan metabolism in allergic rhinitis: The effect of pollen allergen exposure

被引：39

作者：

Ciprandi, Giorgio ^{[1
]}

De Amici, Mara ^{[2
]}

Tosca, Mariangela ^{[3
]}

Fuchs, Dietmar ^{[4
]}

机构：

[1] Univ Genoa, Dept Internal Med, Azienda Osped, Univ San Martino, I-16126 Genoa, Italy

[2] Univ Pavia, Pediat Clin, Fdn IRCCS San Matteo, I-27100 Pavia, Italy

[3] Ist Giannina Gaslini, Pneumol & Allergy Unit, I-16148 Genoa, Italy

[4] Innsbruck Med Univ, Div Biol Chem, Bioctr, Innsbruck, Austria

来源：

HUMAN IMMUNOLOGY | 2010年 / 71卷 / 09期

关键词：

Allergic rhinitis; Serum; Tryptophan; Kynurenine; Pollen allergen exposure; SERUM TRYPTOPHAN; NEOPTERIN;

D O I：

10.1016/j.humimm.2010.05.017

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This study evaluates serum tryptophan, kynurenine, kynurenine-to-tryptophan ratio, and neopterin levels in patients with pollen-induced allergic rhinitis (AR) during and outside of the pollen season, along with these values in healthy subjects. A total of 102 patients (56 female and 46 male, median age 28.7 years) were included in this study: 56 with seasonal AR evaluated outside of the pollen season and thus without allergic inflammation and symptoms, and 46 with seasonal AR evaluated during the pollen season with symptoms. A skin prick test and blood sampling for assessing serum concentrations of tryptophan and kynurenine and of immune activation marker neopterin were performed in all subjects. Tryptophan and kynurenine serum concentrations were higher in AR patients than in controls and were also higher out of pollen season than during this season. In conclusion, this preliminary study demonstrates that serum tryptophan metabolism could serve as a biomarker in patients with AR. (C) 2010 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

引用

页码：911 / 915

页数：5

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