Synthesis of N-substituted indole-2-carboxamides and investigation of their biochemical responses against free radicals

被引：7
|
作者：
Bozkaya, Pinar
Olgen, Sureyya [1 ]
Coban, Tulay
Nebioglu, Dogu
机构：
[1] Ankara Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06100 Ankara, Turkey
[2] Ankara Univ, Fac Pharm, Dept Pharmaceut Toxicol, Ankara, Turkey
来源：
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2007年 / 22卷 / 03期
关键词：
indole-2-carboxamides; reactive oxygen species; superoxide dismutase; lipid peroxidation; inhibition; synthesis;
D O I：
10.1080/14756360601114742
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The antioxidant role of novel N-substituted indole-2-carboxamides (I2CDs) was investigated for their inhibitory effects on superoxide anion (O-2(-)) and lipid peroxidation (LP). Among the synthesized 12CDs, 3, 4, 6, 8 and 9 significantly inhibited O-2(-) with an inhibition range at 70-98%. Examination of substituent effects on activity showed that both the ortho- and parapositions of the benzamide residue needs to be dichlorinated in order to get a maximum inhibitory effect on superoxide anion. In general, halogenated derivatives were found more active then the non-halogenated ones. However, none of the 12CDs had a significant inhibitory effects on the level of lipid peroxidation; only compounds 7 and 10 moderately decreased LP levels by over 50% at 10(-3) M concentrations.
引用
收藏
页码：319 / 325
页数：7
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